Asparaginyl tRNA synthetase polynucleotides of Streptococcus

Details Asparaginyl tRNA synthetase polynucleotides of Streptococcus Asparaginyl tRNA synthetase polynucleotides of Streptococcus

1997-04-18

1998-10-27

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435 6, 4351721, 4353201, 4352523, 43525411, 435325, 536 232, 536 243, C12N 900, C12N 1500, C12N 120, C07H 2104

Patent

active

058277080

ABSTRACT:
The invention provides asnS polypeptides and DNA (RNA) encoding asnS polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing asnS polypeptides to screen for antibacterial compounds.

REFERENCES:
R. Calendar et al., "Purification and Physical Characterization of Tyrosyl Ribonucleic Acid Synthetases from Escherichia coli and Bacillus subtilis", Biochemistry, 5(5) pp. 1681-1690 (1966).
J. Hughes et al., "How Does Pseudomonas Fluorescens, the Producing Organism of the Antibiotic Pseudomonic Acid A, Avoid Suicide?", FEBS Letters, 122(2) pp. 322-324 (1980).
Bruand et al., "Nucleotide sequence of the Bacillus subtilis dnaD gene," Microbiology, 141 pp. 311-322 (1995).
Seignovert et al., "Asparaginyl-tRNA synthetase from Thermus thermophilus HB8. Sequence of the gene and crystallizationof the enzyme expressed in Escherichia coli," Eur. J. Biochem, 239 pp. 501-508 (1996).
Kim et al., "Lactobacillus bulgaricus Asparagine Synthetase and Asparaginyl-tRNA Synthetase: Coregulation by Transcription Antitermination?" Journal of Bacteriology, 178(8) pp. 2459-2461 (1996).
Lindler, et al., "Molecular Cloning and Characterization of a Streptococcus DNase Necessary for Repair of DNA Damage Induced by UV Light and Methyl Methanesulfonate", Journal of Bacteriology, vol. 169, No. 7: pp. 3199-3208, 1987.

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