Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1998-12-16
1999-08-03
Morris, Patricia L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C07D40312
Patent
active
059327421
ABSTRACT:
The present invention relates to a novel arylsulfonylimidazolone derivative represented by the following formula (I) which shows a superior antineoplastic activity in contrast to the known sulfonylurea antitumor agents as well as little side effect: ##STR1## and its pharmaceutically acceptable salt and stereoisomer, in which - -, R.sub.1, and R.sub.2 are as defined in the specification.
REFERENCES:
patent: 4845128 (1989-07-01), Harper et al.
patent: 5110830 (1992-05-01), Harper et al.
patent: 5116874 (1992-05-01), Poore
patent: 5169860 (1992-12-01), Mohamadi et al.
patent: 5254582 (1993-10-01), Boder et al.
patent: 5270329 (1993-12-01), Scott
patent: 5302724 (1994-04-01), Howbert et al.
patent: 5565494 (1996-10-01), Grindey et al.
patent: 5594028 (1997-01-01), Harper et al.
Ji-Wang Chern et al, Journal of Medicinal Chemistry, vol. 40, No. 14, pp. 2276-2286, 1997, "Synthesis and Cytotoxic Evaluation of Substituted Sulfonyl-N-Hydroxyguanidine Derivatives as Potential Antitumor Agents".
Peter J. Houghton et al, Cancer Chemother Pharmacol, vol. 25, pp. 84-88, 1989, "Evaluation of N-(5-Indanylsulfonyl)-N.sup.1 -(4-Chlorophenyl)-Urea Against Xenografts of Pediatric Rhabdomyosarcoma".
J. Jeffry Howbert et al, Journal of Medicinal Chemistry, vol. 33, No. 9, pp. 2393-2407, 1990, "Novel Agents Effective Against Solid Tumors: The Diarylsulfonylureas. Synthesis, Activities, and Analysis of Quantitative Structure-Activity Relationships".
John E. Toth, et al, Journal of Medicinal Chemistry, vol. 40, No. 6, pp. 1018-1025, "Sulfonimidamide Analogs of Oncolytic Sulfonylureas".
Choi Chung Ha
Choi Dong Rack
Chung Yong Ho
Hwang Hyun Sook
Jung Sang Hun
Dong Wha Pharm. Ind. Co. Ltd.
Morris Patricia L.
LandOfFree
Arylsulfonylimidazolone derivatives as an antitumor agent does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Arylsulfonylimidazolone derivatives as an antitumor agent, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Arylsulfonylimidazolone derivatives as an antitumor agent will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-850740