Arylsulfonylimidazolone derivatives as an antitumor agent

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07D40312

Patent

active

059327421

ABSTRACT:
The present invention relates to a novel arylsulfonylimidazolone derivative represented by the following formula (I) which shows a superior antineoplastic activity in contrast to the known sulfonylurea antitumor agents as well as little side effect: ##STR1## and its pharmaceutically acceptable salt and stereoisomer, in which - -, R.sub.1, and R.sub.2 are as defined in the specification.

REFERENCES:
patent: 4845128 (1989-07-01), Harper et al.
patent: 5110830 (1992-05-01), Harper et al.
patent: 5116874 (1992-05-01), Poore
patent: 5169860 (1992-12-01), Mohamadi et al.
patent: 5254582 (1993-10-01), Boder et al.
patent: 5270329 (1993-12-01), Scott
patent: 5302724 (1994-04-01), Howbert et al.
patent: 5565494 (1996-10-01), Grindey et al.
patent: 5594028 (1997-01-01), Harper et al.
Ji-Wang Chern et al, Journal of Medicinal Chemistry, vol. 40, No. 14, pp. 2276-2286, 1997, "Synthesis and Cytotoxic Evaluation of Substituted Sulfonyl-N-Hydroxyguanidine Derivatives as Potential Antitumor Agents".
Peter J. Houghton et al, Cancer Chemother Pharmacol, vol. 25, pp. 84-88, 1989, "Evaluation of N-(5-Indanylsulfonyl)-N.sup.1 -(4-Chlorophenyl)-Urea Against Xenografts of Pediatric Rhabdomyosarcoma".
J. Jeffry Howbert et al, Journal of Medicinal Chemistry, vol. 33, No. 9, pp. 2393-2407, 1990, "Novel Agents Effective Against Solid Tumors: The Diarylsulfonylureas. Synthesis, Activities, and Analysis of Quantitative Structure-Activity Relationships".
John E. Toth, et al, Journal of Medicinal Chemistry, vol. 40, No. 6, pp. 1018-1025, "Sulfonimidamide Analogs of Oncolytic Sulfonylureas".

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Arylsulfonylimidazolone derivatives as an antitumor agent does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Arylsulfonylimidazolone derivatives as an antitumor agent, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Arylsulfonylimidazolone derivatives as an antitumor agent will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-850740

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.