Arylamino fused pyrimidines

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514261, 544254, A01N 4354

Patent

active

061073008

ABSTRACT:
Corticotropin releasing factor (CRF) antagonists of formula I or formula II: ##STR1## and their use in treating anxiety, depression, and other psychiatric and neurological disorders.

REFERENCES:
patent: 4076711 (1978-02-01), Ganguly et al.
patent: 5639752 (1997-06-01), Macor
J. Rivier et al., Proc. Natl. Acad. Sci., 80:4851 (1983).
W. Vale et al., Science, 213:1394 (1981).
W. Vale et al., Rec. Prog. Horm. Res., 39:245 (1983).
G.F. Koob, Persp. Behav. Med., 2:39 (1985).
E.B. De Souza et al., J. Neurosci., 5:3189 (1985).
J.E. Blalock, Physiological Reviews, 69:1 (1989).
J.E. Morley, Life Sci., 41:527 (1987).
E.B. DeSouza, Hosp. Practice, 23:59 (1988).
C.B. Nemeroff et al., Science, 226:1342 (1984).
C.M. Banki et al., Am. J. Psychiatry, 144:873 (1987).
R.D. France et al., Biol. Psychiatry, 23:86 (1988).
M. Arato et al., Biol. Psychiatry, 25:355 (1989).
C.B. Nemeroff et al., Arch. Gen. Psychiatry, 45:577 (1988).
P.W. Gold et al., Am. J. Psychiatry, 141:619 (1984).
F. Holsboer et al., Psychoneuroendocrinology, 9:147 (1984).
P.W. Gold et al., New Eng. J. Med., 314:1129 (1986).
R.M. Sapolsky, Arch. Gen. Psychiatry, 46:1047 (1989).
Grigoriadis et al., Neuropsychopharmacology, 2:53 (1989).
D.R. Britton et al., Life Sci., 31:363 (1982).
C.W. Berridge & A.J. Dunn, Regul. Peptides, 16:83 (1986).
C.W. Berridge & A.J. Dunn, Horm. Behav., 21:393 (1987).
Brain Research Reviews, 15:71 (1990).
K.T. Britton et al., Psychopharmacology, 86:170 (1985).
N.R. Swerdlow et al., Psychopharmacology, 88:147 (1986).
K.T. Britton et al., Psychopharmacology, 94:306 (1988).
G.F. Koob & K.T. Britton, Corticotropin-Releasing Factor: Basic & Clinical Studies of a Neuropeptide, E.B. DeSouza & C.B. Nemeroff, CRC Press, p. 221 (1990).
Remington's Pharmaceutical Sciences, 17.sup.th ed., Mack Pub. Co., Easton, PA, p. 1418 (1985).
Albert, Brown & Wood, J. Chem. Soc., 3832 (1954).
Munson & Rodbard, Anal. Biochem., 107:220 (1980).
G. Battaglia et al, Synapse, 1:572 (1987).
Tanji et al., Chem. Pharm. Bull., 39(11), 3037-3040 (1991).
Settimo et al., Il Farmaco, Ed. Sc., 35(4), 308-323 (1980).
Biagi et al., Il Farmaco, 49(3), 183-186 (1994).
Thompson et al., J. Med. Chem., 34, 2877-2882 (1991).
Kelley et al., J. Med. Chem., 31, 606-612 (1990).
Kelley et al., J. Med. Chem., 33, 1360-1363 (1990).
Kelley et al., J. Heterocyclic Chem., 28, 1099 (1991).
Khairy et al., J. Heterocyclic Chem., 22, 853 (1985).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Arylamino fused pyrimidines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Arylamino fused pyrimidines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Arylamino fused pyrimidines will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-581377

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.