Aryl substituted bicyclic amines as selective dopamine D3 ligand

Details Aryl substituted bicyclic amines as selective dopamine D3 ligand Aryl substituted bicyclic amines as selective dopamine D3 ligand

1997-05-20

2000-07-04

Lambkin, Deborah C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564164, 564167, 514619, 514620, C07C23300, A61K 31165

Patent

active

060841303

ABSTRACT:
Compounds and their pharmaceutically acceptable salts suitable for treating central nervous system disorders associated with the dopamine D3 receptor activity of structural Formula I: ##STR1##

REFERENCES:
patent: 4448990 (1984-05-01), Bach et al.
patent: 4788130 (1988-11-01), Oshiro et al.
patent: 4968679 (1990-11-01), Junge et al.
patent: 5225596 (1993-07-01), Carlsson et al.
Maillard, Jacques; Delaunay, Pierre, Langlois, Michel et Bernard Portevin (Chimie); Jacques Legeai et Chantal Manuel (Pharmacologie);Synthese de derives amines du tetrahydro-4,5,6,7 benzothiazole, Eur. J. Med. Chem.-Chim. Ther., 1984, 19, No. 5, pp. 451-456.
Murray, PJ; Helden, RM; Johnson, MR; Robertson, GM; Scopes, DIC; Stokes, M; Wadman, S; Whitehead, JWF; Hayes, AG; Kilpatrick, GJ; Large, C; Stubbs, CM; Turpin, MP; Novel 6-Substituted 2-Aminotetralins with Potent and Selective Affinity for the Dopamine D.sub.3 Receptor, Bioorganic & Medicinal Chemistry Letters, Vol. 6, No. 4, pp. 403-408, 1996.
Stjernlof, P; Ennis, MD; Hansson, LO; Hoffman, RL; Ghazal, NB; Sundell, S; Smith MW; Svensson,K; Carlsson, A; Wikstrom, H; Structure-Activity Relationships in the 8-Amino-6,7,8,9-tetrahydro-3H-benz[e] indole Ring System. 1. Effects of Substituents in the Aromatic System on Serotonin and Dopamine Receptor Subtypes, J. Med. Chem., 38, 2202-2216 (1995).
Schneider, Claus S., Mierau, Joachin, Dopamine Autoreceptor Agonists: Resolution and Pharmacological Activity of 2,6-Diaminotetrahydrobenzothiazole and an Aminothiazole Analogue of Apomorphine, J. Med. Chem., 1987, 30, 494-498.

Affiliated with

Also associated with

Rating

Aryl substituted bicyclic amines as selective dopamine D3 ligand does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aryl substituted bicyclic amines as selective dopamine D3 ligand, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aryl substituted bicyclic amines as selective dopamine D3 ligand will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1487953