Aryl pyrimidine derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514257, 514826, A61K 31505

Patent

active

059523310

ABSTRACT:
The aryl pyrimidine derivatives and pharmaceutically acceptable salts and N-oxides thereof, exhibit useful pharmacological properties, including utility as selective 5HT.sub.2B -antagonists.

REFERENCES:
patent: 3965101 (1976-06-01), Yale et al.
patent: 4543248 (1985-09-01), Stringfellow et al.
patent: 4619933 (1986-10-01), Stringfellow et al.
patent: 4665077 (1987-05-01), Stringfellow et al.
patent: 5002951 (1991-03-01), Stringfellow et al.
patent: 5147876 (1992-09-01), Mizuchi et al.
patent: 5223505 (1993-06-01), Hargreaves et al.
patent: 5457101 (1995-10-01), Greenwood et al.
patent: 5698444 (1997-12-01), Baez et al.
patent: 5705519 (1998-01-01), Audia et al.
patent: 5736544 (1998-04-01), Audia et al.
Budesinsky et al., Collection Czechoslav. Chem Commun. (1961), vol. 26, pp. 2865-2870, "Uber Die Darstellung Von 2-Sulfanilamido-4-Methylpyrimidinen Mit Einem Heterocyclischen Substituenten in 6-Stellung".
Mariella et al., J. Org. Chem. (1960), vol. 25, pp. 647-648, "Preparation of Various Substituted Pyrimidines".
Zagulyaeva et al., Izv. Sib. Otd. Akad. Nauk SSSR, Ser. Khim. Nauk (1990), vol. 4, pp. 27-31, "Synthesis of Methoxyalkyl Substituted 2-Aminopyrimidines From .Gamma.-Methoxyalkynyl Ketones".
Essawy et al., Egypt. J. Chem. (1994), vol. 37, No. 4, pp. 423-431, "Synthesis and Reactions of 2-Amino-4-Aryl-6-(2'-Methoxynaphthyl)Pyrimidines".
Mokrosz, J.L., et al., Pharmazie (1994) vol. 49, No. 11, pp. 801-806, "Structure-activity relationship studies of CNS agents. Part 14: Structural requirementfor the 5-HT1A and 5-HT2A receptor selectivity of simple 1-(2-pyrimidinyl) piperazine derivatives".
D. Hoyer, et al., Pharmacological Reviews, (1994) vol. 46(2), pp. 157-203, "VII. International Union of Pharmacology Classification of Receptors for 5-Hydroxytryptamine."
G. Martin, et al., Neuropharmacology, (1994) vol. 33(3/4), pp. 261-173, "Classification Review. Reeptors for 5-Hydroxytryptamine: Current Perspectives on Classification and Nomenclature."
Sarosdy et al., "In vivo antitume activity of bropirimine against PAIII and Dunnina MAT-LyLu rodent prostate cancers" (1996) see abstract.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Aryl pyrimidine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aryl pyrimidine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aryl pyrimidine derivatives will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1509959

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.