Aryl and heteroaryl compounds and methods to modulate...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

Reexamination Certificate

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C562S445000

Reexamination Certificate

active

07122580

ABSTRACT:
This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as antagonists, or more preferably, partial antagonist of factor IX and thus, may be used to inhibit the intrinsic pathway of blood coagulation. The compounds are useful in a variety of applications including the management, treatment and/or control of diseases caused in part by the intrinsic clotting pathway utilizing factor IX. Such diseases or disease states include stroke, myocardial infarction, aneurysm surgery, and deep vein thrombosis associated with surgical procedures, long periods of confinement, and acquired or inherited pro-coagulant states.

REFERENCES:
patent: 4675439 (1987-06-01), Mita et al.
patent: 4717736 (1988-01-01), Rokach et al.
patent: 5273990 (1993-12-01), De Lombaert et al.
patent: 5354905 (1994-10-01), Sato et al.
patent: 5397798 (1995-03-01), Fitch et al.
patent: 5514719 (1996-05-01), LaTorse et al.
patent: 5518735 (1996-05-01), Sturzebecher et al.
patent: 5679671 (1997-10-01), Oinuma et al.
patent: 5703106 (1997-12-01), Fruh et al.
patent: 5750520 (1998-05-01), Danilewicz et al.
patent: 5780498 (1998-07-01), Saika et al.
patent: 5908843 (1999-06-01), Gante et al.
patent: 5977075 (1999-11-01), Ksander et al.
patent: 5977178 (1999-11-01), Wise et al.
patent: 6001820 (1999-12-01), Hirsh et al.
patent: 6087380 (2000-07-01), Hauel et al.
patent: 6127341 (2000-10-01), Hansen et al.
patent: 6191171 (2001-02-01), DeLaszlo et al.
patent: 6194448 (2001-02-01), Bredrget et al.
patent: 6194458 (2001-02-01), Baker et al.
patent: 6262084 (2001-07-01), Biediger et al.
patent: 6284871 (2001-09-01), Mertens et al.
patent: 6291511 (2001-09-01), Durette et al.
patent: 6300330 (2001-10-01), Stocker et al.
patent: 6306840 (2001-10-01), Adams et al.
patent: 6331564 (2001-12-01), Brugnara et al.
patent: 6342504 (2002-01-01), Brunk et al.
patent: 6358978 (2002-03-01), Ritzeler et al.
patent: 6362204 (2002-03-01), Head et al.
patent: 6388138 (2002-05-01), Lee et al.
patent: 6388148 (2002-05-01), Heilmann et al.
patent: 6403584 (2002-06-01), De Laszlo et al.
patent: 6420396 (2002-07-01), Albers et al.
patent: 6423727 (2002-07-01), De Lombaert et al.
patent: 6469047 (2002-10-01), Jackson et al.
patent: 6521666 (2003-02-01), Sircar et al.
patent: 6528275 (2003-03-01), Quibell et al.
patent: 6528655 (2003-03-01), N'Zemba et al.
patent: 6559174 (2003-05-01), Lin et al.
patent: 6743790 (2004-06-01), Klingler et al.
patent: 2002/0016461 (2002-02-01), Albers et al.
patent: 2002/0095041 (2002-07-01), Chan et al.
patent: 2002/0103192 (2002-08-01), Curtin et al.
patent: 2002/0151595 (2002-10-01), Ries et al.
patent: 2002/0173656 (2002-11-01), Peyman et al.
patent: 2002/0198195 (2002-12-01), Nazare et al.
patent: 2003/0045480 (2003-03-01), Safar et al.
patent: 2003/0149083 (2003-08-01), Tanaka et al.
patent: 2004/0106626 (2004-06-01), South et al.
patent: 2004/0126856 (2004-07-01), Bajaj et al.
patent: 2004/0152888 (2004-08-01), Bourguignon et al.
patent: 2004/0198780 (2004-10-01), Liu et al.
patent: 2004/0220180 (2004-11-01), Glick et al.
patent: 2004/0241781 (2004-12-01), Glick et al.
patent: 2005/0049310 (2005-03-01), Mjalli et al.
patent: 2005/0053600 (2005-03-01), Lane
patent: 2005/0059705 (2005-03-01), Mjalli et al.
patent: 2005/0059713 (2005-03-01), Mjalli et al.
patent: 2005/0065346 (2005-03-01), Ries et al.
patent: 2005/0165107 (2005-07-01), Inoue et al.
patent: 2005/0187390 (2005-08-01), Schmitz et al.
patent: 2005/0187409 (2005-08-01), Powers et al.
patent: 2005/0203135 (2005-09-01), Burdick et al.
patent: 2005/0256116 (2005-11-01), Clary et al.
patent: 199 28 424 (2000-12-01), None
patent: 0150118 (1987-09-01), None
patent: 1213288 (2002-12-01), None
patent: 2 847 251 (2004-05-01), None
patent: 1 501 541 (1978-02-01), None
patent: 2354440 (2001-03-01), None
patent: 2354440 (2001-03-01), None
patent: 61227555 (1986-10-01), None
patent: 09124569 (1997-05-01), None
patent: 2001-089368 (2001-04-01), None
patent: 2003-321358 (2003-11-01), None
patent: 2004-323487 (2004-11-01), None
patent: WO 95/12611 (1995-05-01), None
patent: WO 1996-33170 (1996-10-01), None
patent: WO 1997-23508 (1997-07-01), None
patent: WO 1997-23508 (1997-09-01), None
patent: WO 1997-40065 (1997-10-01), None
patent: WO 1997-42216 (1997-11-01), None
patent: WO 98/37075 (1998-08-01), None
patent: WO 98/53817 (1998-12-01), None
patent: WO 1998-58950 (1998-12-01), None
patent: WO 99/26923 (1999-06-01), None
patent: WO 99/36393 (1999-07-01), None
patent: WO 9936393 (1999-07-01), None
patent: WO 00/37429 (2000-06-01), None
patent: WO 2000-35864 (2000-06-01), None
patent: WO 00/67746 (2000-11-01), None
patent: WO 00/68188 (2000-11-01), None
patent: WO 00/76971 (2000-12-01), None
patent: WO 01/10823 (2001-02-01), None
patent: WO 01/21584 (2001-03-01), None
patent: WO 01/38309 (2001-05-01), None
patent: WO 2001-056994 (2001-08-01), None
patent: WO 01/68586 (2001-09-01), None
patent: WO 02/18320 (2002-03-01), None
patent: WO 02/26717 (2002-04-01), None
patent: WO 02/062748 (2002-08-01), None
patent: WO 02/085841 (2002-10-01), None
patent: WO 2002-083842 (2002-10-01), None
patent: WO 03/007945 (2003-01-01), None
patent: WO 2003-002545 (2003-01-01), None
patent: WO 2003-006444 (2003-01-01), None
patent: WO 03/033496 (2003-04-01), None
patent: WO 2003-072536 (2003-09-01), None
patent: WO 04/046091 (2004-06-01), None
patent: WO 04/080970 (2004-09-01), None
patent: WO 04/084842 (2004-10-01), None
patent: WO 2004-110983 (2004-12-01), None
patent: WO 2005-012288 (2005-02-01), None
patent: WO 2005-039494 (2005-05-01), None
Burdick et al, “N-Benzoyl Amino Acids as LFA-1/ICAM Inhibitors 1: Amino Acid Structure-Activity Relationship” Bioorganic Medicinal Chemistry Letters, vol. 13, pp. 1015-1018. (2003).
Castanedo et al, “Solid-Phase synthesis of dual alpha4beta1/alpha4beta7 Integrin antagonists: Two Scaffolds with Overlapping Pharmacophores”, Bioorganic & Medicinal Chemistry Letters, Oxford, GB vol. 12, pp. 2913-2917. (2002).
Greenspan P.D. et al., “N-aryl Cinnamides: A Novel Class of Rigid and Highly Potent Leukotriene B4 Receptor Antagonists”, Bioorganic and Medicinal Chemistry Letters, vol. 7, No. 7, 1997, pp. 949-954.
International Search Report for PCT application PCT/US2004/025463 mailed Jan. 26, 2005.
International Search Report for PCT application PCT/US2004/025478 mailed Jan. 26, 2005.
International Search Report for PCT application PCT/US2004/025429 mailed Jan. 26, 2005.
International Search Report for related PCT application PCT/US03/25045 mailed Mar. 14, 2005.
Knowles, H.S. et al., A photochemical approach to phenylalanines and related compounds by alkylation of glycine, Tetrahedron, vol. 57, pp. 98115-98124. (2001).
O'Donnell M.J. et al., “Enantioselective Solid-Phase Synthesis of α-Amino Acid Derivatives”, Tetrahedron, vol. 55, pp. 6347-6362. (1999).
Sircar et al, “Synthesis and SAR of N-benzoyl-L-Biphenylalanine derivatives: Discovery of TR-14035, A Dual Alpha4Beta7/Alpha4Beta1 Intergrin Antagonist”, Bioorganic & Medicinal Chemistry, vol. 10, pp. 2051-2066. (2002).
Bebernitz et al., “Anilides of R-Trifluoro-2-hydroxy-2-methylpropionic Acid as Inhibitors of Pyruvate Dehydrogenase Kinase”, Journal of Medicinal Chemistry, vol. 43, pp. 7121-7124, (2000).
Shrader et al., “Neutral Inhibitors of the Serine Protease Factor Xa”, Bioorganic & Medicinal Chemistry Letters, vol. 11, pp. 1801-1804, (2001).
Knowles et al., “Photochemical alkylation of glycine leading to phenylalanines”, Tetrahedron Letters, vol. 41, pp. 7121-7124, (2000).
Alves et al., “A novel 3-step enantioselective synthesis of pyrenylalanine with subsequent incorporation into opioid, CCK and melanotropin ligands” Biochemical and Biophysical Research Communications, vol. 318, pp. 335-340, (2004).
Amino et al., “Phenylalanine derivatives enhancing intestinal absorption of insulin in mice&

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