Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppress

Details Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppress Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppress

1994-06-21

1996-08-27

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540450, C07D49816

Patent

active

055502334

ABSTRACT:
Aryl, alkyl, alkenyl and alkynyl macrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by oxidation and alkylation at C-4" of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.

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