Aromatic C.sub.16 -C.sub.20 -substituted tetrahydro prostaglandi

Details Aromatic C.sub.16 -C.sub.20 -substituted tetrahydro prostaglandi Aromatic C.sub.16 -C.sub.20 -substituted tetrahydro prostaglandi

1998-09-04

2000-08-22

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514570, 514438, 549 79, 560 60, 562470, 562621, C07C40500, A61K 315575

Patent

active

061073385

ABSTRACT:
The invention provides novel PGF analogs. In particular, the present invention relates to compounds having a structure according to the following formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, X, Y, and Z are defined below. This invention also includes optical isomers, diastereomers and enantiomers of the formula above, and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof.
The compounds of the present invention are useful for the treatment of a variety of diseases and conditions, such as bone disorders and glaucoma. Accordingly, the invention further provides pharmaceutical compositions comprising these compounds. The invention still further provides methods of treatment for bone disorders and glaucoma using theses compounds or the compositions containing them.

REFERENCES:
patent: 4011262 (1977-03-01), Hess
Lijebris, C., Selen, G., Resul, B., Stjernschantz, J., and Hacksell, U., "Dervatives of 17-Phenyl-18, 19,20-trinorprostaglandin F.sub.2.alpha. Isopropyl Ester: Potential Antiglaucoma Agents", Journal of Medicinal Chemistry, vol. 38, No. 2, (1995).
Bundy, G. L., and Lincoln, F. H., "Synthesis of 17-Phenyl-18, 19, 20-Trinoprostaglandins I. The PG.sub.1 Series", Prostaglandins, vol. 9, No. 1, (Jan. 1975).

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