Aromatic amides

Details Aromatic amides Aromatic amides

2005-01-25

2005-01-25

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrolic acids or salts thereof

C562S624000

Reexamination Certificate

active

06846953

ABSTRACT:
Aromatic and heteroaromatic amides of the formulawhere R1, R2and R3can be alkyl, X is alkylene, and R4is an unsubstituted or substituted aromatic or heteroaromatic group such as naphthyl or fluorenyl,are CNS agents useful for treating pain, depression, anxiety, seizures, and schizophrenia.

REFERENCES:
patent: 3016382 (1962-01-01), Wright et al.
patent: 3101339 (1963-08-01), Zeile
patent: 3163654 (1964-12-01), Hiltmann et al.
patent: 3573320 (1971-03-01), Jansen et al.
patent: 4180522 (1979-12-01), Kane et al.
patent: 4186208 (1980-01-01), Kane et al.
patent: 4203988 (1980-05-01), Bolhofer et al.
patent: 4241072 (1980-12-01), Bolhofer
patent: 4260679 (1981-04-01), Tsuda et al.
patent: 4286106 (1981-08-01), Kane et al.
patent: 4293703 (1981-10-01), Bolhofer
patent: 4681898 (1987-07-01), Nadelson
patent: 4877876 (1989-10-01), Tsuji et al.
patent: 4952584 (1990-08-01), Thompson et al.
patent: 5001159 (1991-03-01), Hoornaert et al.
patent: 5075325 (1991-12-01), Hoornaert et al.
patent: 5372932 (1994-12-01), Friedman et al.
patent: 5403842 (1995-04-01), Leonardi et al.
patent: 5453533 (1995-09-01), Luo et al.
patent: 5464788 (1995-11-01), Bock et al.
patent: 5474994 (1995-12-01), Leonardi et al.
patent: 5605896 (1997-02-01), Leonardi et al.
patent: 5654301 (1997-08-01), Kohn et al.
patent: 0 084 292 (1983-07-01), None
patent: 0154190 (1985-09-01), None
patent: 2073286 (1971-01-01), None
patent: 855770 (1960-12-01), None
patent: WO 9813336 (1998-04-01), None
patent: WO 9850343 (1998-11-01), None
Sekiya, CA 113:190946, abstract of JP 02138161, 1990.*
Dombro, CA 60:93472, abstract, Biochem. Pharmacol. 13(4), 569-576, 1964.*
Dombro, CA 63:34608, abstract of Nature, 206(4984), 631-632, 1965.*
Diurno, CA 122:230112, abstract of Med Chem Research, 4(9), 578-587, 1994.*
Elslager et al., “Respiratory Drugs. VIII. Ester and Amide Congeners of Amodiaquine, Hydroxychloroquine, Oxychloroquine, Primaquine, Quinacrine and Related Substances as Potential Long-Acting Antimalarial Agents”,J. Med. Chem.,(1969), vol. 12, No. 4, pp. 600-607.
CA 60: 16390f,Chemical Abstract.
Ronsisvalle et al., “Synthesis and pharmacological properties of N-thienyl alkylenediamines”,Eur. J. Med. Chem.(1988), vol. 23, No., 6, pp. 553-559.
Sugimoto et al., “Studies on the Synthetic Analgesics. XVII. Syntheses of 2-(N-tert-Aminoalkylacylamino)thiophen”,Chem. Pharm. Bull.,(1962), (Tokyo) vol. 10, No. 11, pp. 1061-1064.
Pifferi et al., “Synthesis and Antihypertensive Properties of New 3-Hydrazinopyridazine Derivatives”,J. Med. Chem.,(1975), vol. 18, No. 7, pp. 741-746.
CA 60: 2911e,Chemical Abstract.
Bolhoffer et al., “Inhibitors of Gastric Acid Secretion: Antisecretory 2-Pyridylurea derivatives”,J. Med. Chem.,(1983), vol. 26, No. 4, pp. 538-544.
Geiger et al., “Stereochemical Studies on Drugs, Part 11. Conformation of alkylated 2-acylaminopyridines and their relation with morphine structure”,Eur. J. Med. Chem.,(1982), vol. 17, No. 3, pp. 207-215.
CA 61: 10659 d, e, f,Chemical Abstracts.
Wright, et al., “Synthetic Analgesics. II. Basic Anilides and Carbanilates”,J. Org. Chem.,(1961), vol. 26, pp. 476-485.
Wright, et al., “Synthetic Analgesics. III. Basic Anilides and Carbanilates Containing the Phenalkyl; Moiety”,J. Org. Chem.(1961), vol. 26(2), pp. 485-490.
CA 64: 322e,Chemical Abstracts.
CA 63: 5562f,Chemical Abstracts.
CA 59: 12704h,Chemical Abstracts.
CA 59: 12705a,Chemical Abstracts.
Foussard-Blanpin et al, “Structure-activity relation in local anesthetics. II. Amidines and amides”,Ann. Pharm. Fr.,(1982), vol. 40, No. 3, pp. 231-240.
Courriere et al, “Structure-activity study in a series of local anesthetic agents. I. Physico-chemical properties and molecular orbital study. Correlation with their pharmacodynamical activity”,Eur. J. Med. Chem.,(1978), vol. 13, No. 2, pp. 121-126.
Hiltmann et al, “2-(Acylamino) pyridine derivatives with morphine agonistic and morphine antagonistic properties”,Arzneim.-Forsch.,(1974), vol. 24, No. 4, pp. 584-600.
Eckhardt et al, “Mass spectrometric cleavage of a N-substituent from monoacylated 1,3-diaminopropanes”,Org. Mass Spectrum,(1978), vol. 13, No. 1, pp. 17-19.
Okumura et al., 4-Oxo-1,2,3,4-tetrahydroquinazolines. II. Synthesis of 1-Alkyl-and 1-[2-(Disubstituted amino)ethyl]-2-methyl-3-aryl-4-oxo-1,2,3,4-tetrahydroquinazolines,J. Med. Chem.,(1968), vol. 11, pp. 788-792.
Foussard-Blanpin et al., “Comparative rvations on the inhibition of histamine release by 2-deoxyglucose. Ang.”,Anesth, Analg, Reanim.,(1968), vol. 25, No. 1, pp. 35-43.
Sam et al, “New Compounds: Amides Derived from 2-(2-Pyridyl) ethylamines,”J. Pharm. Sci.,(1967), vol. 56, No. 9, pp. 1202-1205.
CA 62: 14538g,Chemical Abstracts.
CA 61: 1780c,Chemical Abstracts.
CA 59: 13847f,h,Chemical Abstracts.
CA 59: 13848a,Chemical Abstracts.
CA 55: 24612e,f,Chemical Abstracts.
CA 55: 5504i,Chemical Abstracts.
CA 55: 5505a,Chemical Abstracts.
CA 53: 22507a,Chemical Abstracts.
CA 53: 14034e,Chemical Abstracts.
Beilstein Registry No. 3302274.
Beilstein Registry No. 3387876.
Beilstein Registry No. 3403499.
Beilstein Registry No. 3408732.
Beilstein Registry No. 3887209.
Beilstein Registry No. 3888888.
Beilstein Registry No. 3889259.
Beilstein Registry No. 321504.
Beilstein Registry No. 3891877.
Guerrera et al., “Synthesis of 1-alkyl-3-dialkylaminoalkylamine[1]benzothieno[2,3-b]pyrazin-2(1H)-ones and their ability to antagonize KC1-induced contractions”,Eur. J. Med. Chem.,1996), vol. 31, pp. 607-613.
Elslager et al, “Synthetic Schistosomicides. VIII. N-Mono-and N,N-Dialkyl-N′-(4-arylazo-1-naphthyl)alkylenediamines and Related Compounds”,J. Med. Chem.,vol. 9, No. 3, p. 378-91.
Elderfield et al, “Synthesis of Simple 2-Phenyl-8-aminoquinoline Derivatives”,J Amer Chem Soc.,(1946) pp. 1589-1591.
Beilstein Registry No. 281939.
Beilstein Registry No. 302591.
Beilstein Registry No. 339482.

Affiliated with

Also associated with

Rating

Aromatic amides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aromatic amides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aromatic amides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3404044