Arg-Serpin human plasminogen activator inhibitor designated PAI-

Details Arg-Serpin human plasminogen activator inhibitor designated PAI- Arg-Serpin human plasminogen activator inhibitor designated PAI-

1987-02-06

1990-05-08

Martinell, James

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 698, 4352401, 4352523, 43525233, 435255, 435320, 4351723, 536 27, 935 11, 935 69, 935 70, 935 72, 935 73, C12P 2100, C12P 2102, C12N 500, C12N 120

Patent

active

049238078

ABSTRACT:
The invention is directed to an Arg-Serpin human plasminogen activator inhibitor designated PAI-2. This protein is prepared via recombinant DNA means. The invention also includes other serpins which can be made by amino acid substitutions or deletions in conserved regions of PAI-1 and PAI-2, as shown in FIG. 4. The proteins of the invention can be used to inhibit, or at least modulate, human plasminogen activator activity in a variety of physiological conditions, e.g., fibrinolysis, tumor metastasis, and tumor growth.

REFERENCES:
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Ny, T., Sawdey, M., Lawrence, D., Millan, J. L. and Loskutoff, D. J. (1986) Proc. Natl. Acad. Sci. USA 83:6776-6780, "Cloning and Sequence of a cDNA Coding for the Human .beta.-Migrating Endothelial-Cell-Type Plasminogen Activator Inhibitor".
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Scott, R. W., D. L. Eaton, N. Duran, and J. B. Baker (1983) J. Biol. Chem. 258:4397-4403, "Regulation of Extracellular Plasminogen Activator by Human Fibroblasts".

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