Aralykyl (arylethynyl)aralkyl amines and their use as vasodilato

Details Aralykyl (arylethynyl)aralkyl amines and their use as vasodilato Aralykyl (arylethynyl)aralkyl amines and their use as vasodilato

1986-11-19

1988-05-03

Warren, Charles F.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

C07C 8728, A61K 31135

Patent

active

047420847

ABSTRACT:
Acetylenes of the formula (I): ##STR1## wherein Y, m, R.sup.1, R.sup.2, q, Alk, R.sup.3 n and R.sup.4 are as defined herein and Ar.sup.1 and Ar.sup.2 are aromatic, including the salts and ammonium derivatives of formula (I), in treating angina, hypertension and cardiac arrhythmias. Pharmaceutical compositions, methods of use and synthesis and novel intermediates are also part of the invention.

REFERENCES:
patent: 3719712 (1973-03-01), Remy
patent: 4661635 (1987-03-01), Carson
"Antiarrhythmic Agents, 2-, 3- and 4-Substituted Benzylamines", David C. Remy, J. Med. Chem., 1975, vol. 18, No. 2, pp. 142-148.

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