Piperazine derivatives as 5-HT receptors antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514252, 544238, 544295, 544357, 544360, 544393, 564123, A61K 31495, A61K 31505, C07D29515, C07D40104

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active

055322425

ABSTRACT:
##STR1## This invention concerns compounds of formula (I) where A is an alkylene chain of 2 to 5 carbon atoms optionally substituted by one or more lower alkyl groups, R represents hydrogen or one or two same or different lower alkyl groups, R.sup.1 is a monocyclic aryl or heteroaryl radical, R.sup.2 is a mono or bicyclic aryl radical and R.sup.3 is cycloalkyl. The compounds of the invention are useful as antidepressant, antianxiety, or hypotensive agents; or for regulating the sleep/wake cycle, feeding behavior and/or sexual function; and for treating cognition disorders.

REFERENCES:
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patent: 5010078 (1991-04-01), Abou-Gharbia et al.
patent: 5340812 (1994-08-01), Cliffe
Cliffe et al, Chemical Abstracts, vol. 118, No. 169115 (1993) (Abstract for EP 512755, Nov. 11, 1992).

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