Aptamer analogs specific for biomolecules

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 6, 935 77, 935 78, C07H 2104, C07H 2102, C12Q 168

Patent

active

058408673

ABSTRACT:
Oligonucleotide sequences that mediate specific binding to selected target molecules and contain modified base, sugars, or sugar linkages are disclosed. Single-stranded DNA oligomers are obtained that bind to a series of biomolecules that differ in both size and composition. The range of target molecules that may be bound permits generation of binding oligomers that are specific for binding to nearly any biomolecule that is composed of amino acids, lipids and/or carbohydrates. The binding oligomers are useful for therapeutic, diagnostic and manufacturing purposes.

REFERENCES:
patent: 4647529 (1987-03-01), Rodland et al.
patent: 4748156 (1988-05-01), Aoki et al.
patent: 5133866 (1992-07-01), Kauvar
patent: 5270163 (1993-12-01), Gold et al.
Fenton II et al., "Thrombin Anion-binding Exosite Interactions with Heparin and Various Polyanions," Annals New York Academy of Sciences Jul. 8, 1991 pp. 158-165.
Oliphant et al., "Defining the consensus sequences of E. coli promoter elements by random selection," Nucl. Acids Res. 16(5):7673-7683 (1988).
Oliphant et al., "Defining the Sequence Specificity of DNA-Binding Proteins by Selecting Binding Sites from Random-Sequence Oligonucleotides: Analysis of Yeast GCN4 Protein," Mol. and Cell. Biol. 9(7):2944-2949 (1989).
Chittenden et al., "The T/E1A-Binding Domain of the Retinoblastoma Product Can Interact Selectively with a Sequence-Specific DNA-Binding Protein," Cell 65:1073-1082 (Jun. 14, 1991).
Abelson, "Directed Evolution of Nucleic Acids by Independent Replication and Selection," Science (1990) 240:488-489.
Otvos et al., "Substrate specificity of DNA polymerases. I. Enzyme-catalysed incorporation of 5-(1-alkenyl)-2'-deoxyuridines into DNA," Nucl. Acid Res (1987) pp. 1763-1777.
Allen et al., "Fluoresence Oligonucleotides and Deoxynucleotide Triphosphates: Preparation and Their Interaction with the Large (Klenow) Fragment of Escherichia coli DNA Polymerase I," Biochemistry (1989) 28:4601-4607.
Langer et al., "Enzymatic synthesis of biotin-labeled polynucleotides: Novel nucleic acid affinity probes," Proc. Natl. Acad. Sci. USA (1981) 78:6633-6637.
Gebeyehu et al., "Novel biotinylated nucleotide -- analogs for labelling and colorimetric detection of DNA," Nucleic Acids Res (1987) 15:4513.
Gillam et al., "N.sup.4 (6-Aminohexyl)cytidine and -deoxycytidine Nucleotides Can Be Used to Label DNA," Anal. Biochem. (1986) 199-207.
Trainor et al., "A procedure for the preparation of fluorescence-labeled DNA with terminal deoxynucleotidyl transferase," Nucl. Acid Res. (1988) 16:11846.
Mizusawa et al., "Improvements of the dideoxy chain termination method of DNA sequencing by use of deoxy-7-deazaguanosine triphosphate in place of dGTP," Nucl. Acid Res. (1986) 14:1319-1324.
Evans et al., "Synthesis and Biological Properties of 5-Azido-2'-deoxyuridine 5'-Triphosphate, a Photoactive Nucleotide Suitable for Making Light-Sensitive DNA," Biochemistry (1987) 26:269-276.
Evans et al., "5-Azido-2'-deoxyuridine 5'-triphosphate: A photoaffinity-leveling reagent and tool for the enzymatic synthesis of photoactive DNA," Proc. Natl. Acad. Sci. USA (1986) 83:5832-5386.
Dale et al., "The Synthesis and Enzymatic Polymerization of Nucleotides Containing Mercury: Potential Tools for Nucleic Acid Sequencing and Structural Analysis," Proc. Natl. Acad. Sci. USA (1973) 70:2238-2242.
Prober et al., "A System for Rapid DNA Sequencing with Fluoresence Chain-Terminating Dideoxynucleotides," Science 238:336-341.
Valko et al., "Correlation of Nucleotide Incorporation Rate and PHLA Retention Parameters of Substituted Nucleosides," J. Liq. Chromatography (1989) 12(11):2103-2116.
Valko et al., "Application of chromatographic retention data in an investigation of quantitative structure -- nucleotide incorporation rate relationship," J. Chromatography (1990) 506:35-44.
Huynh-Dinh et al. Proc. Natl. Acad. Sci. (1985) 82:7510-7514.
Nishikawa A., "Chromatograhy, Affinity," Kirk-Othmer, Encyclopedia of Chemical Technology (1979) John Wiley & Sons, New York, Third Edition, 6:35-54.
Blackwell et al., Science (1990) 250:1104-1110.
Blackwell et al., Science (1990) 250:1149-1152.
Tuerk and Gold, Science (1990) 249:505-510.
Joyce, G.F., Gene (1989) 82:83-87.
Kinzler and Vogelstein, Nucleic Acids Res. (1989) 17:3645-3653.
Kinzler and Vogelstein, Mol. Cell Biol. (1990) 10:634-642.
Ellington and Szostak, Nature (1990) 346:818-822.
Thiesen and Bach, Nucleic Acids Res. (1990) 18(11):3203-3208.
Oliphant et al., "The Use of Random-Sequence Oligonucleotides for Determining Consensus Sequences," Methods in Enzymology, 155:568-582 (1987).
Andrake et al., "DNA polymerase of bacteriophage T4 is an autogenous translational repressor," PNAS, 85:7942-7946 (Nov. 1988).
Hanson et al., "Interruption of acute platelet-dependent thrombosis by the synthetic antithrombin-D-pheylalanyl-L-arginyl chloromethyl ketonen," PNAS, USA, 85:3184-3188 (May 1988).
Prescott et al., "Human endothelial cells in culture produce platelet-activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when stimulated with thrombin," PNAS, USA 81:3534-3538, (Jun. 1984).
Shaw et al., "Modified deoxyoligonucleotides stable to exonuclease degradation in serum," Nucl. Acids Res., 19(4):747-750 (1991).
Riordan et al., "Oligonucleotide-based therapeutics," Nature, 350:442-3 (Apr. 4, 1991).
Kirk-Othmer, "Encyclopedia of Chemical Technology," 3rd Ed. 6 (1979) J. Wiley & Sons (N.Y.) pp. 35-54.
Lestienng et al.., Biochimie 65:49-52 (1983).
Zon, Pharm. Res. 5(9):539-549.
Lehninger, Biochemistry, 2.sup.th ed., Worth Publishers, Inc., 1975. 1104 pp. 1013-1014.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Aptamer analogs specific for biomolecules does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aptamer analogs specific for biomolecules, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aptamer analogs specific for biomolecules will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1703611

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.