Application of 2-bromide-isovanillin for the manufacture of...

Details Application of 2-bromide-isovanillin for the manufacture of... Application of 2-bromide-isovanillin for the manufacture of...

2011-07-19

2011-07-19

Fetterolf, Brandon J (Department: 1628)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Aldehyde doai

Reexamination Certificate

active

07981939

ABSTRACT:
Use of 2-bromo-isovanillin in the preparation of an anticancer medicament and/or radio- and chemotherapy sensitizing medicament is disclosed. The medicament for the treatment of cancers and/or for radio- and chemotherapy sensitization comprising 2-bromo-isovanillin as active ingredient provided herein has the following features: (1) low toxicity, without evident adverse effects; (2) significant therapeutic effect, with remarkable proliferation inhibiting and pro-apoptotic effects in tumor cells; (3) a broad-spectrum anticancer activity; (4) suitable to be used in combination with antimetabolites, to enhance the effects and meanwhile lower the toxicity, and also to reduce multi-drug resistance; (5) convenient and safe administration, the main route being oral.

REFERENCES:
patent: 6812258 (2004-11-01), Bessette et al.
patent: 7008649 (2006-03-01), Bessette et al.
patent: 2002/0182268 (2002-12-01), Bessette et al.
patent: 2003/0017218 (2003-01-01), Bessette et al.
patent: 2004/0146595 (2004-07-01), Bessette et al.
patent: 1154355 (1997-07-01), None
patent: 1329498 (2002-01-01), None
patent: 0758639 (1997-02-01), None
Trost et al. Divergent enantioselective synthesis of (−)-galanthamine and (−)-morphine. J. Am. Chem. Soc. 2005, 127, 14785-14803.
Univar. Excipients/Processing Aids. Mar. 1, 2005.
Zhenshun et al., “The Synthetic Methods and Usage of Vanillin”, China Food Additives, No. 6, pp. 101-106, 2004.
Durant et al., “Vanillins-a Novel Family of DNA-PK Inhibitors”, Nucleic Acids Research, vol. 31, No. 19, pp. 5501-5512, 2003.
Tsuda et al., “Chemopreventive Effects of β-Carotene, α-Tocopherol and Five Naturally Occurring Antioxidants on Initiatoin of Hepatocarcinogenesis by 2-Amino-3-methylimidazo[4,5-ƒ]quinoline in the Rat”, Jpn. J. Cancer Res., 85, pp. 1214-1219, 1994.
International Search Report from PCT/CN2006/002191.

Affiliated with

Also associated with

Rating

Application of 2-bromide-isovanillin for the manufacture of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Application of 2-bromide-isovanillin for the manufacture of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Application of 2-bromide-isovanillin for the manufacture of... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2721304