Image analysis – Applications – Biomedical applications
Patent
1998-07-22
2000-10-24
Tran, Phuoc
Image analysis
Applications
Biomedical applications
382134, 382226, 382228, G06K 900
Patent
active
061378992
ABSTRACT:
A free-lying cell classifier. An automated microscope system comprising a computer and high speed processing field of view processors identifies free-lying cells. An image of a biological specimen is obtained and the image is segmented to create a set of binary masks. The binary masks are used by a feature calculator to compute the features that characterize objects of interest including free-lying cells, artifacts and other biological objects. The objects are classified to identify their type, their normality or abnormality or their identification as an artifact. The results are summarized and reported. A stain evaluation of the slide is performed as well as a typicality evaluation. The robustness of the measurement is also quantified as a classification confidence value. The free-lying cell evaluation is used by an automated cytology system to classify a biological specimen slide.
REFERENCES:
patent: 3824393 (1974-07-01), Brain
patent: 4097845 (1978-06-01), Bacus
patent: 4122518 (1978-10-01), Castleman et al.
patent: 4175860 (1979-11-01), Bacus
patent: 4183013 (1980-01-01), Agrawala et al.
patent: 4199748 (1980-04-01), Bacus
patent: 4513438 (1985-04-01), Graham et al.
patent: 4523278 (1985-06-01), Reinhardt et al.
patent: 4538299 (1985-08-01), DeForest
patent: 4709333 (1987-11-01), Crawford
patent: 4724543 (1988-02-01), Klevecz et al.
patent: 4731860 (1988-03-01), Wahl
patent: 4965725 (1990-10-01), Rutenberg
patent: 4973111 (1990-11-01), Haacke et al.
patent: 4975972 (1990-12-01), Bose et al.
patent: 5016283 (1991-05-01), Bacus et al.
patent: 5086479 (1992-02-01), Bacus
patent: 5162990 (1992-11-01), Odeyale et al.
patent: 5231005 (1993-07-01), Russell et al.
patent: 5253302 (1993-10-01), Massen
patent: 5268967 (1993-12-01), Jang et al.
patent: 5281517 (1994-01-01), Bacus et al.
patent: 5287272 (1994-02-01), Rutenberg et al.
patent: 5315700 (1994-05-01), Johnston et al.
patent: 5361140 (1994-11-01), Hayenga et al.
patent: 5889881 (1999-03-01), MacAulay et al.
Bacus, James W. and Les J. Grace, "Optical Microscope System for Standardized Cell Measurements and Analyses", Applied Optics, 26:16, pp. 3280-3293, Aug. 15, 1987.
Bartels, Peter H., et al., "A Self-Learning Computer Program for Cell Recognition", ACTA Cytologica: The Journal of Clinical Cytology, 14:8, pp. 486-494, Oct. 1970.
Duda, Richard O. and Peter E. Hart, "Fisher's Linear Discriminant", Patent Classification and Scene Analysis, Copyright .COPYRGT. 1973, pp. 114-119.
Mackin, Robert W., Badrinath Roysam et al., "Automated Three-Dimensional Image Analysis of Thick and Overlapped Clusters in Cytologic Preparations: Application to Cytologic Smears", Analytical and Quantitative Cytology and Histology, 15:6, Dec. 1993, pp. 405-417.
Otsu, Nobuyuki, "A Threshold Selection Method from Gray-Level Histograms", IEEE Transactions on Systems, Man. and Cybernetics, vol. SMC-9, No. 1, Jan. 1979.
Dytch, Harvey E. et al., "An Interactive Microcomputer-Based System for the Quantitative Analysis of Stratified Tissue Sections", Analytical and Quantitative Cytology and Histology, vol. 9, No. 1, pp. 69-78, Mar. 1987.
Tanaka, Noboru et al., "Automated Cytologic Screening System (Cybest Model 4): an Integrated Image Cytometry System", Reprinted from Applied Optics, vol. 26, pp 3301, Aug. 15, 1987. Copyright .COPYRGT. 1987 by the Optical Society of America and reprinted by premission of the copyright owner.
Enslein, Kurt and Peter W. Neurath, "Augmented Stepwise Discriminant Analysis Applied to Two Classification Problems in the Biomedical Field", Computers and Biomedical Research, 2, 568-581 (1969).
Kurman, Robert J. et al., "Part 1: Specimen Adequacy" and "Part 2: Descriptive Diagnoses", The Bethesda System for Reporting Cervical/Vaginal Cytologic Diagnoses, Springer-Verlag.
Weber, J.E. et al., "Fuzzy Reasoning, Possibility Theory and Probability Theory in Expert Systems for Histopathology", IEEE/Ninth Annual Conference of the Engineering in Medicine and Biology. Society, pp. 1560-1562, .COPYRGT.1987.
Wied, G.L. et al., "Expert Systems as Classifiers in Diagnostic Cytopathology", IEEENninth Annual Conference of the Engineering in Medicine and Biology Society, pp. 1915-1917,.COPYRGT.1987.
Wied, G.L. et al., "Expert System Design Under Incertainty of Human Diagnosticians", IEEE/Eighth Annual Conference of the Engineering in Medicine and Biology Society, pp. 757-760, .COPYRGT.1986.
Wied, G.L. et al., "Ticas-Stratex, an Expert Diagnostic System For Stratified Cervical Epithelium", IEEE/Ninth Annual Conference of the Engineering in Medicine and Biology Society, pp. 1557-1559, .COPYRGT.1987 .
Serra, J., Image Analysis and Mathematical Morphology, pp. 372-423, Academic Press, 1982.
Smith, Warren J., "Image Evaluation", Modern Optical Engineering, McGraw-Hill Book Company, 1966, pp. 308-325.
Patten, Jr., Stanley, "Dianostic Cytopathology of the Uterine Cervix", Basel, Switzerland, Publisher: S. Karger, 1969, 2nd Edition 1978, Third volume in Monographs in Clinical Cytology, edited by G.L. Wied, pp. 10-15.
Lee, James S.J. et al., "A Processing Strategy for Automated Papanicolaou Smear Screening", Analytical and Quantitative Cytology and HIstology, vol. 14, No. 5, Oct. 1992, pp 415-425.
Bannister Wendy R.
Kuan Chih-Chau L.
Lee Shih-Jong J.
Meyer Michael G.
Oh Seho
Leone George
Moffa Emil
Sun Hans
Tran Phuoc
Tri Path Imaging, Inc.
LandOfFree
Apparatus for the identification of free-lying cells does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Apparatus for the identification of free-lying cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Apparatus for the identification of free-lying cells will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1973047