Chemistry: analytical and immunological testing – Tracers or tags
Patent
1994-06-10
1996-01-09
Housel, James C.
Chemistry: analytical and immunological testing
Tracers or tags
25036303, 376199, 472 81, 472903, 436 57, 436813, 436174, G01N 3700
Patent
active
054828651
ABSTRACT:
A handling and processing apparatus for preparing Oxygen-15 labeled water (H.sub.2 [.sup.15 O]) in injectable form for use in Positron Emission Tomography from preferably H.sub.2 [.sup.15 O] produced by irradiating a flowing gas target of nitrogen and hydrogen. The apparatus includes a collector for receiving and directing a gas containing H.sub.2 [.sup.15 O] gas and impurities, mainly ammonia (NH.sub.3) gas into sterile water to trap the H.sub.2 [.sup.15 O] and form ammonium (NH.sub.4.sup.+) in the sterile water. A device for displacing the sterile water containing H.sub.2 [.sup.15 O] and NH.sub.4.sup.+ through a cation resin removes NH.sub.4.sup.+ from the sterile water. A device for combining the sterile water containing H.sub.2 [.sup.15 O] with a saline solution produces an injectable solution. Preferably, the apparatus includes a device for delivering the solution to a syringe for injection into a patient. Also, disclosed is a method for preparing H.sub.2 [.sup.15 O] in injectable form for use in Positron Emission Tomography in which the method neither requires isotopic exchange reaction nor application of high temperature.
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Alexoff David
Ferrieri Richard A.
Schlyer David J.
Associated Universities Inc.
Bogosian Margaret C.
Housel James C.
Soderquist Arlen
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