Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-04-15
1996-07-23
Housel, James C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
356136, 356301, 356352, 385 12, 385 36, 422 55, 422 57, 422 8205, 422 8208, 422 8211, 435 71, 4352872, 4352887, 435808, 436164, 436172, 436518, 436527, 436805, G01N 33552
Patent
active
055388507
ABSTRACT:
The presence of trace materials in a sample is detected using both macroscopic and microscopic properties. A detector includes a light source and an optical resonator. The light source may be located either inside the resonance cavity of the resonator or outside the cavity, in which case it may be a semi-conductor such as a semi-conductor laser or a superluminescent diode. The detector also includes at least one reflective member that has a total internal reflection (TIR) surface and may be a passive device or an active gain element. Light from the light source is preferably focussed onto a single point of reflection on the TIR surface. The test sample is positioned within the evanescent field region of the TIR surface. Optical changes arising within the evanescent field region, such as excitation of fluorescence in the sample, changes in its refractive index, and changes in the resonant frequency of the optical resonator, are then detected. These changes are then sensed to determine the amount or at least presence of analyte located at the TIR surface.
REFERENCES:
patent: 4857273 (1989-08-01), Stewart
patent: 5229833 (1993-07-01), Stewart
patent: 5341215 (1994-08-01), Seher
patent: 5344784 (1994-09-01), Attridge
patent: 5350697 (1994-09-01), Swope et al.
patent: 5437840 (1995-08-01), King et al.
Steven J. Choquette et al. "Planar Waveguide Immunosensor With Fluorescent Liposome Amplification", 1992, vol. 64(1), pp. 55-60, Analytical Chemistry.
Wolfgang Demtr oder, Laser Spectroscopy, Springer-Verlag, Berlin, pp. 390-395.
A. P. Godlevskii et al. "Intracavity Adsorption Spectroscopy of Surface-Active Substances, Adsorbed Gases, and Aerosols", 1979, vol. 29, pp. 1301-1304, J. Appl. Spect.
N. J. Harrick, Internal Reflection Spectroscopy, Interscience Publishers, New York, 1967, pp. 147-177.
J. H. Jerman et al. "A miniature Fabry-Perot interferometer with a corrugated silicon diaphragm support", 1991, vol. 29, pp. 151-158, Sensors and Actuators.
Thomas J. Kane et al. "Monolithic, unidirectional single-mode Nd:YAG ring laser", 1985, vol. 10 (2), pp. 65-67, Optics Letters.
R. P. H. Kooyman et al. "A fiber-optic fluorescence immunosensor", vol. 798, 1987, pp. 290-293, Proc. Soc. Photo-opt. Instrum. Eng.
William J. Kozlovsky et al. "Efficient Second Harmonic Generation of a Diode-Laser-Pumped CW Nd: YAG Laser Using Monolithic MgO: LiNbO.sub.3 External Resonant Cavities", 1988, vol. 24 (6), pp. 913-919, IEEE Journal of Quantum Electronics.
Mel N. Kronick et al., "A New Immunoassay Based on Fluorescence Excitation by Internal Reflection Spectroscopy", 1975, vol. 8, pp. 235-240, Journal of Immunological Methods.
Y. Liu et al. "An Integrated Optical Sensor for Measuring Glucose Concentration", 1992, vol. B 54, pp. 18-23, Applied Physics B.
Paul Lorrain et al. Electromagnetic Fields and Waves, W. H. Freeman and Company, San Francisco, 1962, pp. 504-515.
W. Lukosz, "Principles and sensitivities of integrated optical and surface plasmon sensors for direct affinity sensing and immunosensing", 1991, vol. 6, pp. 215-225, Biosensors and Bioelectronics.
Konan Peck et al. "Single-molecule fluorescence detection: Autocorrelation criterion and experimental realization with phycoerythrin", 1989, vol. 86, pp. 4087-4091, Proc. Natl. Acad. Sci. USA.
Dror Sarid et al. "Optical field enhancement by long-range surface-plasma waves", 1982, vol. 21 (22), pp. 3993-3995, Applied Optics.
Anthony E. Siegman, Lasers, University Science Books, Mill Valley, California, 1986, pp. 524-527.
S. Schiller et al. "Fused-silica monolithic total-internal-reflection resonator", 1992, vol. 17 (5), pp. 378-380, Optics Letters.
A. N. Sloper et al. "A Planar Indium Phosphate Monomode Waveguide Evanescent Field Immunosensor", 1990, vol. B1, pp. 589-591, Sensors and Actuators.
Steven A. Soper et al. "Single-Molecule Detection of Rhodamine 6G in Ethanolic Solutions Using Continuous Wave Laser Excitation", 1991, vol. 63 (5), pp. 432-437, Analytical Chemistry.
King David A.
Seher Jens-Peter
Chin Christopher L.
Hewlett--Packard Company
Housel James C.
LandOfFree
Apparatus and method for intracavity sensing of microscopic prop does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Apparatus and method for intracavity sensing of microscopic prop, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Apparatus and method for intracavity sensing of microscopic prop will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-712134