Apovincaminic acid esters

Details Apovincaminic acid esters Apovincaminic acid esters

1982-06-11

1984-10-02

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D46100, A61K 31475

Patent

active

044749600

ABSTRACT:
A process is disclosed for the preparation of racemic cis or trans apovincaminic acid esters of the formula (I) ##STR1## and the corresponding optically active derivatives of the formulae (Ia) ##STR2## wherein R.sup.1 and R.sup.2 are identical or different alkyl groups having 1 to 6 carbon atoms. Apovincaminic acid alkyl esters are well-known vasodilating compounds.

REFERENCES:
patent: 4316029 (1982-02-01), Rossey

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