Aporphine esters and their use in therapy

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C546S075000

Reexamination Certificate

active

10344420

ABSTRACT:
New aporphine derivatives are disclosed which have formula (I) and the physiologically acceptable salts thereof. Said derivatives may be used for the treatment of Parkinson's disease, hemicrania, restless legs syndrome (RLS), sexual dysfunction in men and women, hyperprolactemia and psychotic disorders, and/or evaluation of Parkinson's disease. Processes for the preparation of such derivatives are also disclosed.

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STN International, File CAPLUS CAPLUS accession No. 1981:47565, document No. 94:47565 J.F. Green et al.: “Aporphines. XXVI: GLC and mass spectrometric properties of trifluoroacetyl derivatives of N-methyl-, N-propyl-, and noraporphines”.
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J. F. Green, et al., “Aporphines XXVI: GLC and Mass Spectrometric Properties of Trifluoroacetyl Derivatives of N-Methyl-, N-Propyl-, and Noraporphines”, Journal of Pharmaceutical Sciences, vol. 69, No. 8, Aug. 1980, pp. 936-942.
D. Michael Baaske, et al., “Gas Chromatographic Determination of Apomorphine in Plasma”, Journal of Chromatography, vol. 140, 1977, pp. 57-64.

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