Apoptosis proteins

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S320100, C435S004000, C435S006120, C530S350000

Reexamination Certificate

active

09762491

ABSTRACT:
The present invention is directed to novel apoptosis polypeptides such as the Apop1, and Apop3 proteins and related molecules which are involved in modulating apoptosis and to nucleic acid molecules encoding those polypeptides. Also provided here are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which modulate the biological activity of Apop1, Apop2, and Apop3, and the use of such compositions in diagnosis and treatment of disease.

REFERENCES:
patent: 6096539 (2000-08-01), Gomes et al.
patent: 6267956 (2001-07-01), Gomes et al.
patent: WO 96/36730 (1996-11-01), None
patent: WO 97/15586 (1997-05-01), None
Wang, J. et al. 2000 J. Biol. Chem. 275 (1): 507-513.
Cao, et al., “Human Gastric Adenocarcinoma Cathepsin B: Isolation and Sequencing of Full-Length cDNAs and Polymorphisms of the Gene”,Gene(1994), vol. 139, pp. 163-169.
Chan, et al., “Nucleotide and Predicted Amino Acid Sequences of Cloned Human and Mouse Preprocathespin B cDNAs”,Proceedings of the National Academy of Sciences USA(1986), vol. 83, pp. 7721-7725.
Cohen, Gerald, M., “Caspases: the Executioners of Apoptosis”,Biochemistry Journal(1997), vol. 326, pp. 1-16.
Del Peso, L., et al., “Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt”,Science(1997), vol. 278, pp. 687-689.
Fong, D., et al., Isolation of a cDNA Clone for the Human Lysosomal Proteinase Cathepsin B,Proceedings of the National Academy of Sciences USA(1986), vol. 83, pp. 2909-2913.
Moin, K., et al., “Human Tumour Cathepsin B—Comparison with Normal Liver Cathepsin B”,Biochemical Journal(1992), vol. 285, pp. 427-434.
Nägler, D. et al., “Full-Length cDNA of Human Cathespin F Predicts the Presence of a Cystatin Domain at the N-terminus of the Cysteine Protease Zymogen”,Biochemical and Biophysical ResearchCommunications (1999) vol. 257, pp. 313-318.
Ritonja, A., et al., “Amino Acid Sequence of Human Liver Cathespin B”,Federation of European Biochemical Societies, (1985), vol. 181, No. 1, pp. 169-172.
Santamaria, I., et al., “Molecular Cloning and Structural and Functional Characterization of Human Cathespin F, a New Cysteine Proteinase of the Papain Family with a Long Propeptide Domain”,Journal of Biological Chemistry(1999), vol. 274, No. 20, pp. 13800-13809.
Sun, X., et al.,The Journal of Biological Chemistry(1999), vol. 274, No. 24, pp. 16871-16875.
Takahashi, R., et al., A Single BIR Domain of XIAP Sufficient for Inhibiting Caspases,The Journal of Biological Chemistry(1998), vol. 273, No. 14, pp. 7787-7790.
Thome, M., et al., “Syk and ZAP-70 Mediate Recruitment of p56lck/CD4 to the Activated T Cell Receptor CD3/ζ Complex”,Journal of Experimental Medicine(1995), vol. 181, pp. 1997-2006.
Wang, B., et al., “Human Cathespin F—Molecular Cloning, Functional Expression, Tissue Localization, and Enzymatic Characterization”,Journal of Biological Chemistry(1998), vol. 273, No. 48, pp. 32000-32008.
Wex, TH., et al. “Human Cathepsins F and W: A New Subgroup of Cathepsins”,Biochemical and Biophysical Research Communications(1999), vol. 259, pp. 401-407.
Yu , P., et al., “Identification of RIP3, a RIP-like Kinase That Activates Apoptosis and NFκB”,Current Biology(1999), vol. 9, pp. 539-542.
Accession No. NM—001908, submitted Aug. 29, 2002.
Accession No. M14221, submitted 1986.
Accession No. P07858, submitted Jul. 1, 1989.
Accession No. NP—001899, submitted 1986.
Accession No. AF071748, submitted Jun. 9, 1998.
Accession No. NM—003793, submitted Oct. 15, 1999.
Accession No. AF088886, submitted May 3, 1999.
Accession No. AJ007331, submitted Jun. 20, 1998.
Accession No. AF132894, submitted Mar. 3, 1999.
Accession No. AA338898, submitted Apr. 21, 1997.
Accession No. H39591, submitted Jul. 31, 1995.
Accession No. AA378321, submitted Apr. 21, 1997.
Accession No. AA227673, submitted Nov. 27, 1996.
Accession No. N99896, submitted Apr. 15, 1996.
Accession No. AI394293, submitted Feb. 4, 1999.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Apoptosis proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Apoptosis proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Apoptosis proteins will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3823024

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.