Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
2009-02-23
2011-12-27
Kosar, Andrew D (Department: 1622)
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
C544S395000
Reexamination Certificate
active
08084607
ABSTRACT:
Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
REFERENCES:
patent: 5138069 (1992-08-01), Carini et al.
patent: 6410584 (2002-06-01), Pamukcu et al.
patent: 6720338 (2004-04-01), Augeri et al.
patent: 7030115 (2006-04-01), Elmore et al.
patent: 7358251 (2008-04-01), Elmore et al.
patent: 7390799 (2008-06-01), Bruncko et al.
patent: 7449485 (2008-11-01), Elmore et al.
patent: 7504512 (2009-03-01), Augeri et al.
patent: 7585858 (2009-09-01), Elmore et al.
patent: 7642260 (2010-01-01), Bruncko et al.
patent: 7767684 (2010-08-01), Bruncko et al.
patent: 2002/0086887 (2002-07-01), Augeri et al.
patent: 2003/0119894 (2003-06-01), Murthy et al.
patent: 2006/0258657 (2006-11-01), Bruncko et al.
patent: 2007/0015787 (2007-01-01), Bruncko et al.
patent: 2007/0072860 (2007-03-01), Bruncko et al.
patent: 2008/0076779 (2008-03-01), Elmore et al.
patent: 2008/0287419 (2008-11-01), Bruncko et al.
patent: 2009/0318689 (2009-12-01), Franczyk et al.
patent: 2010/0240715 (2010-09-01), Bruncko et al.
patent: 230136 (1991-12-01), None
patent: WO 02/24636 (2002-03-01), None
patent: WO 02/098848 (2002-12-01), None
patent: WO 03/040107 (2003-05-01), None
patent: WO 03/080586 (2003-10-01), None
patent: WO 2004/043950 (2004-05-01), None
patent: WO 2004/048329 (2004-06-01), None
patent: WO 2005/049593 (2005-06-01), None
patent: WO 2005/049594 (2005-06-01), None
PCT International Preliminary Examination Report dated May 15, 2006, in International Application No. PCT/US2004/036770, filed Nov. 3, 2004.
PCT International Preliminary Examination Report dated May 15, 2006, in International Application No. PCT/US2004/037911, filed Nov. 12, 2004.
PCT International Search Report dated May 13, 2005, in International Application No. PCT/US2004/036770, filed Nov. 3, 2004.
PCT International Search Report dated May 13, 2005 in International Application No. PCT/US2004/037911, filed Nov. 12, 2004.
Banker, Gilbert S. et al., Modem Pharmaceuticals, Marcel Dekker, New York, 1996.
Corbett et al., 2003, “Discovery and preclinical antitumor efficacy evaluations of LY32262 and LY33169,” Investigational New Drugs, vol. 21:33-45.
Wolff, Manfred E., Burger's Medicinal Chemistry and Drug Discovery, Fifth Ed. vol. 1: Principles and Practice, John Wiley & Sons, 1995, 975.
Degterev, et al., “Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL,” Nature Cell Biology, 2001, vol. 3, pp. 173-182.
Enyedy, et al., “Discovery of Small-Molecule Inhibitors of Bcl-2 through Structure-Based Computer Screening,” J. Med. Chem., 2001, 44, pp. 4313-4324.
Kutzki, et al., “Development of Potent Bcl-xl Antagonist Based on α-Helix Mimicry,” J. Am. Chem. Soc., 2002, 124, pp. 11838-11839.
Oltersdorf, et al., “An inhibitor of Bcl-2 Family proteins induces regression of solid tumours”, Nature, 2005, 4 35, pp. 677-681.
Tse et al., “ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor,” Cancer Research May 1, 2008, 68(9), pp. 3421-3428.
Wang, et al., “Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells,” PNAS, Jun. 20, 2000, vol. 97, No. 13, pp. 7124-7129.
Wang, et al., “A novel small molecule inhibitor of Bcl-XLinhibits tumor growth in a human head and neck squamous cell carcinoma xenograft model,” Proceedings of the American Association for Cancer Research, Jul. 2003, vol. 44, 2ndEd., p. 942, #4740 Abstract.
Wang, et al., “An Efficient Synthesis of ABT-263, a Novel Inhibition of Anti-apoptotic Bcl-2 Proteins,” Synthesis, 2008, 15, pp. 2398-2404.
Amendment and Response filed on Oct. 8, 2009 in U.S. Appl. No. 11/600,445.
Final Office Action mailed Aug. 12, 2009 for U.S. Appl. No. 12/120,914, filed May 15, 2008.
Hattori, et al., CAS Accession No. 2006:298664.
Non-final Office Action mailed Nov. 28, 2008 for U.S. Appl. No. 12/120,914, filed May 15, 2008.
Bruncko Milan
Ding Hong
Elmore Steven
Kunzer Aaron R.
Lynch Christopher L.
Abbott Laboratories
Jones Day
Kosar Andrew D
Leeser Erich A
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