Apo AI/CIII genomic polymorphisms predictive of atherosclerosis

Details Apo AI/CIII genomic polymorphisms predictive of atherosclerosis Apo AI/CIII genomic polymorphisms predictive of atherosclerosis

1985-09-30

1989-01-31

Warden, Robert J.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435810, 436 63, 436 14, 436503, 536 27, 935 11, 935 78, 935 79, C12Q 168, G01N 33567

Patent

active

048015318

ABSTRACT:
The invention offers an early detection method for atherosclerosis using genetic analysis to detect a polymorphisms shown to be correlated with this disease which are proximal to the apolipoprotein AI (apoAI) and aplipoprotein CIII (apoCIII) gene complex. All individuals with a 300 bp deletion 4 kb upstream of the apoAI gene are destined to experience severe atherosclerotic symptomologies. Individuals with a polymorphism 5.4 kb 5' of the apoAI gene or a PvuII polymorphism in the first intron of the apoCIII gene also seem to be at greater risk. A haplotype with MspI and XmnI/7.2 polymorphisms in this general region seem to be protected. Additional polymorphic sites in the DNA sequence associated with the apoAI/CIII gene complex provide a means for genetically fingerprinting individuals, and for identifying persons at risk with respect to disorders relating to lipid metabolism and transport.

REFERENCES:
patent: 4623619 (1986-11-01), Owerbach et al.
Rees et al., "DNA Polymorphism Adjacent to Human Apo-Protein A-1 Gene . . . ", The Lancet, Feb. 26, 1983, pp. 444-446.
Karathanasis et al., "An Inherited Polymorphism in the Human Apolipoprotein A-1 Gene . . . ", Nature 301, 718-720 (1983).
Wallis et al., "The Isolation of a Genomic Clone Containing the Apolipoprotein CII Gene . . . ", Hum. Genet 68, 286-289 (1984).
Fojo et al., "Analysis of the Apo C-II Gene . . . ", Biochem Biophys Res. Comm. 124(1), 308-313 (1984).
Seilhamer, J. J., et al., "Isolation and DNA Sequence . . . Discovery of a New Genetic Polymorphism in the Apo AI Gene", DNA 3(4), 309-317 (1984).
Antonarakis, W. E. et al., Proc. Natl. Acad. Sci. (USA) (1983) 79:137.
Gianelli et al., Lancet (1984) i:2369, 4 Feb.
Grunebaum et al., J. Clin. Invest. (1984) 73:1491.
Gusella, J. F. et al., Nature (1983) 306:234.
Jeffreys, A. J., Cell (1979) 18:1-10.
Kan, Y. W. et al., Proc. Natl. Acad. Sci. (USA) (1978) 75:5631.
Ostyer, H. et al., Am. J. Hum. Gen. (1984) 36(Supp):150S.
Phillips, J. A., III, Banbury Report 14, Cold Spring Harbor Laboratory (1983) pp. 305-315.
Rotwein, P. et al., Science (1981) 213:1117.
Southern, E., J. Mol. Biol. (1975) 98:503-517.
Woo, S.L.C. et al., Nature (1983) 306:151.

Affiliated with

Also associated with

Rating

Apo AI/CIII genomic polymorphisms predictive of atherosclerosis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Apo AI/CIII genomic polymorphisms predictive of atherosclerosis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Apo AI/CIII genomic polymorphisms predictive of atherosclerosis will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-177259