Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1995-05-25
1998-07-21
Ulm, John
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530828, 930 10, C07K 1447
Patent
active
057836663
ABSTRACT:
A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.
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Joslyn, et al., "Identification of Delection Mutations and Three New Genes at the Familial Polyposis Locus", Cell, 66:601-613 (1991).
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Fearon et al., "Identification of a Chromosome 18q Gene That is Altered in Colorectal Cancer", Science, 247:49-56 (1990).
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Albertsen Hans
Anand Rakesh
Carlson Mary
Groden Joanna
Hedge Philip John
Saoud Christine
The Cancer Institute
The Johns Hopkins University
The University of Utah
Ulm John
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