Antiviral peptide derivatives having a 2-oxoalkyl amino acid sid

Details Antiviral peptide derivatives having a 2-oxoalkyl amino acid sid Antiviral peptide derivatives having a 2-oxoalkyl amino acid sid

1995-10-11

1997-12-23

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, 530329, 530330, 530331, A61K 3800, C07K 500

Patent

active

057007802

ABSTRACT:
--CH(R.sup.2)--C(W.sup.1)!.sub.n --NH--CR.sup.3 --(R.sup.8)--COOH!--C(W.sup.4)--NH--CR.sup.9 (R.sup.10)--Z wherein X is a terminal group, for example, alkanoyl or phenylalkanoyl radicals, R.sup.1 is hydrogen, alkyl or phenylalkyl, R.sup.2, R.sup.4 and R.sup.10 am selected from amino acid or derived amino acid residues, R.sup.3, R.sup.5, R.sup.6, R.sup.7, R.sup.8 and R.sup.9 are hydrogen or alkyl, or R.sup.7 and R.sup.8 are joined to form a cycloalkyl, W.sup.1, W.sup.2, W.sup.3 and W.sup.4 are oxo or thioxo, Y is, for example, an alkyl or a cycloalkyl, Z is a terminal group, for example, COOH or CH.sub.2 OH, and n is 0 or 1. The derivatives are useful for treating herpes infections.

REFERENCES:
patent: 4795740 (1989-01-01), Cohen et al.
patent: 4814432 (1989-03-01), Freidinger et al.
patent: 4837304 (1989-06-01), Garsky et al.
patent: 4845195 (1989-07-01), Colonno et al.
patent: 5502036 (1996-03-01), Adams et al.
Gaudreau et al., J. Biol. Chem. vol. 262, No. 26, pp. 12413-12416, Sep. 1987.

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