Drug – bio-affecting and body treating compositions – Lymphokine – Interferon
Reissue Patent
1999-09-06
2009-08-25
Li, Ruixiang (Department: 1646)
Drug, bio-affecting and body treating compositions
Lymphokine
Interferon
C424S085500, C424S085600, C424S085700, C424S078070
Reissue Patent
active
RE040882
ABSTRACT:
The present invention can be used in pharmacology specifically in the preparation of interferon-containing compositions, which are capable of conserving their biological activity and can be administered intranasally, e.g. in the preparation of nasal drops. This invention essentially refers to an antiviral agent in the form of nasal drops that contains a genetically engineered alpha, beta or gamma interferon with a viscosity of (1.1−30.0)*delete-start id="DEL-S-00001" date="20090825" ?10delete-end id="DEL-S-00001" ?insert-start id="INS-S-00001" date="20090825" ?10−3insert-end id="INS-S-00001" ?Pascal .second, a biocompatible polymer and a buffer mixture. The agent may further include an antioxidant, and the ingredients are contained in the following amounts per ml buffer mixture: 1,000 todelete-start id="DEL-S-00002" date="20090825" ?5,000delete-end id="DEL-S-00002" ?insert-start id="INS-S-00002" date="20090825" ?500,000insert-end id="INS-S-00002" ?IU of genetically engineered interferon; 0.005 to 0.714 g of biocompatible polymer; and 0.0001 to 0.0008 g of an antioxidant. TRILON B® (disodium salt of EDTA) is used as the antioxidant, whereas polyvinylpyrrolidone and/or polyethylene oxide is (are) used as the biocompatible polymer(s) at polyvinylpyrrolidone/polyethylene oxide ratio of 1:1-50.
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Inventor's Certificate 297296, Ershov F.L.,Medicina, p. 216 (1996).
Gaponyuk Petr Jakovlevich
Markov Iliya Alexandrovich
Markova Elena Alexeevna
Ladas & Parry LLP
Li Ruixiang
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