Antisense oligonucleotides directed against nucleic acids encodi

Details Antisense oligonucleotides directed against nucleic acids encodi Antisense oligonucleotides directed against nucleic acids encodi

1994-10-25

1997-01-07

Campell, Bruce R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 235, 514 44, 935 8, 935 34, C07H 2104

Patent

active

055918409

ABSTRACT:
The present invention is directed to oligodeoxynucleotides which are capable of hybridizing to genes which encode NF-.kappa.B. The oligodeoxyribonucleotides are antisense to NF.kappa.B genes and when hybridized prevent the production of NF.kappa.B transcription factor by the NF.kappa.B genes, and thereby provide a means for preventing cellular adhesion.

REFERENCES:
patent: 5138045 (1992-08-01), Cook et al.
patent: 5225326 (1993-07-01), Bresser et al.
Sommer and Tautz, Nucleic Acids Research, vol. 17, No. 16, 1989, p. 6749.
Ruben et al., Molecular and Cellular Biology 12:444-454 (1992) "Functional characterization of the NF-.kappa.B p. 65 transcriptional activator and an alternatively spliced derivative".
Chiang et al., Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanisms, J. Biol. Chem. 266:18162-18171 (1991).
Calabretta, Inhibition of protooncogene expression by antisense oligodeoxynucleotides: biological and therapeutic implications, Cancer Research 51:4505-4510 (Sep. 1, 1991).
Landreth et al., Insulin-like growth factor-I regulates pro-B cell differentiation, Blood 80:1207-1212 (Sep. 1, 1992).
Denhardt, Antisense strategies come of age, The New Biologist, vol. 4, No. 5, pp. 473-481 (May 1992).
Abelda and Buck, Integrins and other cell adhesion molecules, FASEB J. 4:2868-2880 (Aug. 1990).
Lewin, Oncogenic conversion by regulatory changes in transcription factors, Cell 64:303-312 (Jan. 25, 1991).
Synthesis, vol. 1, No. 1 (Antisense Molecular Biology and "S-oligos") (Oct. 1988).
Lawlor and Narayanan, Persistent expression of the tumor suppressor gene DCC is essential for neuronal diffentiation, Cell Growth & Differentiation 3:609-616 (1992).
Narayanan et al., Antisense RNA to the putative tumor-suppressor gene DCC transforms Rat-1 fibroblasts, Oncogene 7:553-561 (1992).
Chiang et al., J. Biol. Chem. 266:18162-18171 (1991).
Calabretta, Cancer Research 51:4505-4510 (Sep. 1, 1991).
Landreth et al., Blood 80: 1207-1212 (Sep. 1, 1992).
Denhardt, The New Biologist, vol. 4, No. 5, pp. 473-481 (May 1992).
Albelda and Buck, FASEB J. 4:2868-2880 (Aug. 1990).
Lewin, Cell 64:303-312 (Jan. 25, 1991).
Synthesis, vol. 1, No. 1 (Antisense Molecular Biology and "S-oligos") (Oct. 1988).
Lawlor and Narayanan, Cell Growth & Differentiation 3:609-616 (1991).
Narayanan et al., Oncogene 7:553-561 (1992).
New England Biolabs 1988-89 Catalog, p. 62.
Bennet (1996) Science 271: 434.
Milligan et al (1993) J Med Chem 36:1923-1937.
Westermann et al. (1989) Biomed. Biochim. Acta 48:85-93.
Ruben, S. et al. Science 251:1490-1493 (1991).
Narayanen et al. Science 256: 367-370 (1992).
Ghosh et al. Cell 62: 1019-1029 (1990).
Kieran et al. Cell 62: 1007-1018 (1990).
Kitajima, et al. Atlation of Transplanted HTLV-1 Tax-Transformed Tumors in Mice by Antisense Inhibition of NF-.sub..kappa. B, Science 258, 1792-1795 (1992).
Higgins, et al. Antisense inhibition of the p65 subunit of NF-.sub..kappa. B blocks tumorigenicity and causes tumor regression, Proc. Natl. Acad. Sci, 90 9901-9905, (1993).
Narayanan, et al, Evidence For Differential Functions of the P50 and P65 Subunits of NF-Kappab With a Cell Adhesion Model, Mol. Cell Biol. 13 3802-3810 (1993).
Sokoloski, et al. Antisense Oligonucleotides to the P65 Subunit of NF-Kappa-B Block CD11B Expression And Alter Adhesion Properties of Differentiated HL-60 Granulocytes 82 625-632 (1993).

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