Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1992-03-31
1995-10-10
Zitomer, Stephanie W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C07H 2104, A61K 4800
Patent
active
054571898
ABSTRACT:
Oligonucleotides are provided which are capable of antisense interaction with messenger RNA of papillomavirus. Such oligonucleotides or oligonucleotide analogs can be used for diagnostics and therapeutics as well as for research purposes. In accordance with preferred embodiments of this invention, oligonucleotide ISIS 2105 is provided which hybridizes with selected messenger RNA from a human papillomavirus. The oligonucleotide is able to inhibit the function of the RNA, and accordingly is useful for therapy for infections by such papillomavirus.
In accordance with a preferred embodiment, portions of the papillomavirus are targeted for antisense attack. Thus oligonucleotides are preferably provided which hybridize with the E2, E6 and E7 messenger RNAs.
REFERENCES:
Chin et al., "Regulation of Human Papillomavirus Type 11 Enhancer and E6 Promoter . . . ", J. Virol. 62(8):2994-3002 (1988/Aug.).
Cole et al., "Nucleotide Sequence and Comparative Analysis of the Human Papillomavirus Type 18 Genome", J. Mol. Biol. 193:599-608 (1987).
van der Krol et al., "Modulation of Eukaryotic Gene Expression by Complementary RNA or DNA Sequences", BioTechniques 6(10):958-976 (1988).
Androphy, E. J., et al., Bovine papillomavirus E2 trans-activating gene product binds to specific sites in papillomavirus DNA, Nature 325:70-73 (1987).
Amtmann, E. & Sauer, G., Bovine Papillomavirus Virus Transcription: Polyadenylated RNA Species and Assessment of the Direction of Transcription, J. Virol. 43:59-66 (1982).
Baker, C. C. & Howley, P. M., Differential promoter utilization by the bovine papillomavirus in transformed cells and productively infected wart tissues, EMBO J. 6:1027-1035 (1987).
Berg, L. J., et al., Complementation of a Bovine Papilloma Virus Low-Copy-Number Mutant: Evidence for a Temporal Requirement of the Complementing Gene, Mol. Cell. Biol. 6:859-869 (1986).
Boshart, M., et al., A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer, EMBO J. 3:1151-1157 (1984).
Burnett, S., et al., Messenger RNAs from the E1 region of bovine papillomavirus type 1 detected in virus-infected bovine cells, Nucleic Acids Res. 15:8607-8620 (1987).
Chen, E. Y., et al., The primary structure and genetic organization of the bovine papillomavirus type 1 genome, Nature 299:529-534 (1982).
Cowsert, L. M., et al., Topographical and Conformational Epitopes of Bovine Papillomavirus Type 1 Defined by Monoclonal Antibodies, JNCI 79:1053-1057 (1987).
Cowsert, L. M. et al., Identification of the Bovine Papillomavirus L1 Gene Product Using Monoclonal Antibodies, Virology 165:613-615 (1988).
Dahlberg, A. E., et al., Eelctrophoretic Characterization of Bacterial Polyribosomes in Agarose-Acrylamide Composite Gels, J. Mol. Biol. 41:39 (1969).
Dartmann, K., et al., The Nucleotide Sequence and genome Organization of Human Papilloma Virus Type 11, Virology 151:124-130 (1986).
Durst, M., et al., A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions, Proc. Natl. Acad. Sci. USA 80:3812-3815 (1983).
DiMaio, D., Nonsense Mutation in Open Reading Frame E2 of Bovine Papillomavirus DNA, J. Virol. 57:475-480 (1986).
DiMaio, D. & Settleman, J., Bovine papillomavirus mutant temperature sensitive for transformation, replication and transctivation, EMBO J. 7:1197-1204 (1988).
Dvoretzky, I. et al., A quantitative in vitro focus assay for bovine papilloma virus, Virology 103:369-375 (1980).
Engel, L. W., et al., Transcriptional Organization of Bovine Papillomavirus Type 1, J. Virol. 47:516-528 (1983).
Frost, E. and Williams, J., Mapping Temperature-Sensitive and Host-Range Mutations of Adenovirus Type 5 by Marker Rescue, Virology 91:39-50 (1978).
Gissmann, L., et al., Human papillomavirus types 6 and 11 DNA seuqences in genital and laryngeal papillomas and in some cervical cancers, Proc. Natl. Acad. Sci. USA 80:560-563 (1983).
Gius, D., et al., Inducible and Constitutive Enhancer Domains in the Noncoding Region of Human Papillomavirus Type 18, J. Virol. 62:665-672 (1988).
Graham, F. L. and van der Eb, A. J., A New technique for the Assay of Infectivity of Human Adenovirus 5 DNA, Virology 52:456-461 (1973).
Groff, D. E. & Lancaster, W. D., Genetic Analysis of the 3" Early Region Transformation and Repliation Functions of Bovine Papillomavirus Type 1, Virology 150:221-230 (1986).
Groman, C. M. et al., Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells, Mol. Cell. Biol. 2:1044-1051 (1982).
Heilman, C. A., et al., Virus-Specific Transcription in Bovine Papillomavirus-Transformed Mouse Cells, Virology 119:22-34 (1982).
Herbomel et al., Two Distinct Enhancers with Different Cell Specificities Coexist in the Regulatory Region of Polyoma, Cell 39:653 (1984).
Hirochika, H., et al., Enhancers and trans-Acting E2 Transcriptional Factors of Papillomaviruses, J. Virol. 61:2599-2606 (1987).
Iyer, R. P., et al., The Automated Synthesis of Sulfur-Containing Oligodeoxyribonucleotides Using 3H-1,2-Benzodithiol-3-one 1,1 Dioxide as a Sulfure-Transfer Reagent, J. Org. Chem. 55:4693-4699 (1990).
Lambert, P. F., et al., A Transcriptional Repressor Encoded by BPV-1 Shares a Common Carboxy-Terminal Domain with the E2 Transactivator, Cell 50:69-78 (1987).
Lusky, M. & Botchan, M. R., Genetic Analysis of Bovine Papillomavirus Type 1 trans-Acting Replication Factors, J. Virol. 53:955-965 (1985).
Lusky, M. & Botchan, A Bovine Papillomavirus Type 1-Encoded Modulator Function is Dispensable for Transient Viral Replication but is Required for Establishment of the Stable Palsmid State, M.R., J. Virol. 60:729-742 (1986).
Maniatis et al. (Maniatis, T., Fritsch, E. F. and Sambrook, J. Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, New York, 1982.
McBride, A. A., et al., The carboxy-terminal domain shared by the bovine papillomavirus E2 transactivator and repressor proteins contains a specific DNA binding activity, EMBO J. 7:533-539 (1988).
Moskaluk, C. & Bastia, D., The E2 "gene" of bovine papillomavirus encodes an enhancer-binding protein, Proc. Natl. Acad. Sci. USA 84:1215-1218 (1987).
Phelps, W. C. et al., The Human Papillomavirus Type 16 E7 Gene Encodes Transactiviation and Transformation Functions Similar to Those of Adenovirus E1A, Cell 53:539-547 (1988).
Phelps, W. C. & Howley, P. M., Transcriptional trans-Activation by the Human Papillomavirus Type 16 K2 Gene Product, J. Virol. 61:1630-1638 (1987).
Rabson, M. S., et al., Bovine Papillomavirus Type 1 3" Early Region Transformation and Plasmid Maintenance Functions, J. Virol. 60:626-634 (1986).
Roberts, J. M. & Weintraub, H., Negative Control of DNA Replication in Composite SV40-Bovine Papilloma Virus Plasmids, Cell 46:741-752 (1986).
Sarver, N., et al., Localization and Analysis of Bovine Papillomavirus Type 1 Transforming Functions, J. Virol. 52:377-388 (1984).
Spalholz, B. A., et al., Transactivation of a Bovine Papilloma Virus Transcriptional Regularoty Element by the K2 Gene Product, Cell 42: 183-191 (1985).
Spalholtz et al., Bovine Papillomavirus Transcriptional Regulation: Localization of the E2 Responsive Elements of the Long Control Region, J. Virol. 61:2128-2137 (1987).
Spalholz, B. A., et al., Evidence for Cooperativity Between K2 Binding Sites in K2 trans-Regulation of Bovine Papillomavirus Type 1, J. Virol. 62:3143-3150 (1988).
Stenlund, A., et al., Messenger RNAs from the Transforming Region of Bovine Papilloma Virus Type 1, J. Mol. Biol. 182:541-554 (1985).
Thierry, F. & Yaniv, M., The BPV1-E2 trans-acting protein can be either an activator or a repressor of the HPV18 regulatory region, EMBO J. 6:3391-3397 (1987).
Yang, Y. C., et al., Bovine Papillomavirus Contains Multiple Transforming Genes, Proc. Natl. Acad. Sci. USA 82:1030-1034 (1985).
Zur Hausen, H. and Schneider, A., The Papovaviridae, vol. 2, pp. 245-264, edited by N. P. Salzman and P. M. Howley, Plenum Press, New York, 1987, The Role of Papillomaviruses in Human Anogenital Cancer.
Cowsert Lex M.
Crooke Stanley T.
Ecker David J.
Mirabelli Christopher K.
ISIS Pharmaceuticals
Licata Jane Massey
Zitomer Stephanie W.
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