Antisense of oligonucleotides to c-kit proto-oncogene and in vit

Details Antisense of oligonucleotides to c-kit proto-oncogene and in vit Antisense of oligonucleotides to c-kit proto-oncogene and in vit

1995-06-05

1999-11-23

Crouch, Deborah

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

435 5, 435325, 435372, 536 245, 514 44, C12Q 102, C12Q 168, C12N 500, A61K 4800

Patent

active

059898496

ABSTRACT:
Oligonucleotides are provided having a nucleotide sequence complementary to at least a portion of the mRNA transcript of the human c-kit gene. These "antisense" oligonucleotides are hybridizable to the c-kit mRNA transcript. Such oligonucleotides are useful in selectively inhibiting proliferation of erythroid cells, particularly in disorders characterized by an elevated hematocrit due to over-production of erythrocytes. The antisense oligomers also have activity agent hematologic neoplastic cells and are therefore suitable as bone marrow purging agents.

REFERENCES:
patent: 5087617 (1992-02-01), Smith
Stein et al (1993) Science 261, 1004-1012.
Weiss (1991) Science News 139-108-109.
Tseng et al (1994) Cancer Gene Therapy 1, 65-71.
James (1991) Antiviral Chem. Chemother. 2, 191-214.
Cleary et al (1998) Cell 47, 19-28.
Linnenbach et al (1988) Proced. Nat. Acad. Sci. 85, 74-78.
Strohmeyer et (1991) Canc. Res. 51, 1811-1816.
Slamm et al (1989) Science 244, 707-712.
Majello et al (1986) Proced. Natl. Acad. Sci. 83, 9636-9640.
McGrath et al (1983) Nature 304, 901-904.
Caracciolo et al (1989) Science 245, 1107-1110.
Yarden et al (1987) EMBOJ 6, 3341-3351.
Orr-Urtregiv et al (1990) Develop. 109, 911-923.
Ratajczak et al (1992) Proced. Natl. Acad. Sci: 89, 11823-11827.
Ratajczak et al (1992) Blood 79, 1956-1961.
Smith et al (1986) Aust. NZ J. Med. 16, 39-42.
Park et al (1980) Blood 55, 595-601.
Gustavsson et al (1984) Canc. Res. 44, 4648-4652.
Veerman et al (1990) Brit. J. Hematology 74, 381-384.

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