Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1991-09-24
1993-04-06
Killos, Paul J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
560227, 562605, 562840, 514460, 514550, 514863, 514824, 549292, C07C 6976, C07C 6963
Patent
active
052005496
ABSTRACT:
The invention relates to compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or methyl; ##STR2## wherein R.sub.2 is lower alkyl; R.sub.3 is phenyl, or phenyl substituted by 1 to 3 substituents selected from the group consisting of halo, lower alkyl, and lower alkoxy; and R.sub.4 is hydrogen or methyl or the corresponding hydroxy acid of formula ##STR3## and R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as described above; or a pharmaceutically acceptable salt of said acid, a C.sub.1-4 alkyl ester of said acid, an acetylamino-substituted-C.sub.1-4 alkyl ester of said acid, a phenyl-dimethylamino ester of said acid or a .alpha.-monoglyceride of said acid.
The compounds of formulas I and II are useful as agents for the treatment of hyperproliferative skin diseases such as psoriasis.
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Goldstein Ann
McLane John A.
Uskokovic Milan R.
Wovkulich Peter M.
Gould George M.
Hoffman-La Roche Inc.
Johnston George W.
Kass Alan P.
Killos Paul J.
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