Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-01-24
2006-01-24
Powers, Fiona T. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S311000, C514S312000, C514S343000, C514S365000, C514S392000, C514S422000, C514S424000, C514S542000, C544S354000, C546S169000, C546S278400, C548S200000, C548S306100, C548S374100, C548S467000, C548S517000, C548S525000, C548S550000, C560S041000, C560S043000
Reexamination Certificate
active
06989384
ABSTRACT:
Compounds of the formula:where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picomaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.
REFERENCES:
patent: 5856530 (1999-01-01), Webber et al.
patent: 5962487 (1999-10-01), Webber et al.
Webber et al., Chemical Abstracts, 131:45107, 1999.
Birch, G. et al., “Purification Of Recombinant Human Rhinovirus 14 3C Protease Expressed InEscherichia coli” Protein Expression And Purification1995, 609-618, vol. 6.
Bundgaard, H. et al. , Design of Prodrugs, 1985, Elsevier Press.
Diana, G. et al., “Picornavirus Inhibitors: Trifluoromethyl Substitution Provides A Global Protective Effect Against Hepatic Metabolism”J. Med. Chem.1995, 1355-1371, vol. 38.
Dragovich, P. et al., “Solid-Phase Synthesis Of Irreversible Human Rhinovirus 3C Protease Inhibitors. Part 1: Optimization Of Tripeptides Incorporating N-Terminal Amides”Bioorganic&Medicinal Chemistry1999, 589-598, vol. 7.
Dragovich, P. et al., “Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 3. Structure-Activity Studies Of Ketomethylene-Containing Peptidomimetics”J. Med. Chem.1999, 1203-1212, vol. 42.
Dragovich, P. et al., “Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 4. Incorporation of P1Lactam Moieties as L-Glutamine Replacements,”J. Med. Chem.1999, 1213-1224, vol. 42.
Weislow, et al.,J. Natl. Cancer Inst.1989, 577-586, vol. 81.
Chan Fora P.
Chu Shao Song
Eastman Brian Walter
Hendrickson Thomas F.
Hua Ye
Agouron Pharmaceuticals , Inc.
Neidert Karl
Powers Fiona T.
Zielinski Bryan C.
LandOfFree
Antipicornaviral compounds and compositions, their... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antipicornaviral compounds and compositions, their..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antipicornaviral compounds and compositions, their... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3555604