Antineoplastic agent-entrapping liposomes

Details Antineoplastic agent-entrapping liposomes Antineoplastic agent-entrapping liposomes

1988-02-08

1990-03-06

Terapane, John F.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

4284022, A61K 3722, A61J 500, B01J 1302, B32B 516

Patent

active

049064770

ABSTRACT:
Some of antineoplastic agents, for instance, adriamycin and daunorubicin, have a positive charge at physiological pH. Such drugs possess high affinity for binding to steroidal sulfate by means of electrostatic force. The invention utilizes this property to prepare steroidal sulfate liposomes having a net negative charge and encapsulating the antineoplastic agent.

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Gabizon A. et al., "Liposome Formulations With Prolonged Circulation Time", Proc. Natl. Acad. Sci. USA, vol. 85, pp, 6949-6953, (1988).
Kurono et al., Chem Abs., vol. 110, No. 18, "Antineoplastic Agent-Entrapping Liposomes", abs. #160396b.
Cullis et al., "Liposomes as Pharmaceuticals", in Liposomes From Biophysics to Therapeutics, Astro ed., Marcel Dekker, 1987, pp. 53-65.

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