Antiinflammatory, analgesic, and antirheumatic 4-hydroxy-2-methy

Details Antiinflammatory, analgesic, and antirheumatic 4-hydroxy-2-methy Antiinflammatory, analgesic, and antirheumatic 4-hydroxy-2-methy

1983-08-31

1985-10-01

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544 48, C07D51304, A61K 3154

Patent

active

045446555

ABSTRACT:
4-Hydroxy-2-methyl-3-(2-pyridylcarbamoyl)-6-trifluoromethyl-2H-thieno[2,3-e ]-1,2-thiazine 1,1-dioxide of the formula ##STR1## and its pharmaceutically acceptable salts which possess valuable pharmacodynamic properties are described. More particularly, the compound and its salts display antiinflammatory, analgesic and antirheumatic activities and they are readily accessible by reacting a corresponding alkyl ester with 2-aminopyridine and, if desired, subsequent salt formation.

REFERENCES:
patent: 4076709 (1978-02-01), Hromatka et al.
patent: 4180662 (1979-12-01), Pfister et al.
patent: 4224445 (1980-09-01), Hromatka et al.
Harry L. Yale, The Trifluoromethyl Group in Medicinal Chemistry, J Med and Pharm Chem, VI, No. 2, 1959, p. 121.

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