Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1989-07-28
1992-05-05
Lee, Lester L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
548344, A61K 3700, C07D23364
Patent
active
051107996
ABSTRACT:
A series of carboxyl-containing N-alkyldipeptides have been found to posess antiviral potency--specifically against herpes simplex virus--by selectively inhibiting the viral ribonucleotide reductase enzyme.
REFERENCES:
patent: 3632753 (1972-01-01), Elton et al.
patent: 3790438 (1973-06-01), Cook et al.
patent: 4374829 (1983-02-01), Harris, Jr. et al.
patent: 4752602 (1988-06-01), Apsky et al.
patent: 4795740 (1989-01-01), Cohen et al.
patent: 4814432 (1989-03-01), Freidinger et al.
patent: 4863904 (1989-09-01), Iizuka
E. Nicholaides, et al., Potential Antiviral Agents, J. Med. Chem., II, 74 (1968).
E. A. Cohen et al., Nature, 321: 441-443 (1986) III.
B. M. Dutia et al., Nature, 321: 439-441 (1986).
P. Gaudreau et al., J. of Biological Chem., 262: 12413-12416 (1987).
Blumenstein et al., "Synthetic Non-peptide Inhibitors of HIV Protease," Biochem. Biophys. Res. Comm., 163, No. 2 (1989) pp. 980-987.
Denkewalter et al., "Progress in Dry Research", vol. 10 (1966) p. 510-512.
Bryer, Medicinal Chem. 2nd ed. Jun. 27, 1960, Interscience Publishers Inc., p. 565-601.
Plattner et al., J. Med., Chem. 1988, 31, pp. 2277-2288 Renin Inhibitor, Dipeptide Analogues of a Protein.
Ashton Wallace T.
Tolman Richard L.
Wu Mu T.
Bencen Gerard H.
Kraus E. J.
Lee Lester L.
Merck & Co. , Inc.
Pfeiffer Hesna J.
LandOfFree
Antiherpetic agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antiherpetic agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antiherpetic agents will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1412514