Antigenic peptides

Details Antigenic peptides Antigenic peptides

2005-07-20

2011-12-20

Swartz, Rodney P. (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

C424S184100, C424S190100, C424S234100, C424S248100, C530S300000, C530S350000

Reexamination Certificate

active

08080251

ABSTRACT:
The present invention relates to peptide antigens of SEQ ID Nos. 1 to 10; repeat motif Gly-X-Gly-Asn-X-Gly of SEQ ID No. 11; and a method of developing drug against tuberculosis, said method comprising steps of targeting the proposed drug towards peptide antigens of SEQ ID Nos. 1 to 11, and thereby developing the drug against tuberculosis.

REFERENCES:
patent: 5585461 (1996-12-01), Townsend et al.
patent: 5807746 (1998-09-01), Lin et al.
patent: 6043339 (2000-03-01), Lin et al.
patent: 6440663 (2002-08-01), Scanlan et al.
patent: 6461618 (2002-10-01), Chen et al.
patent: 6495518 (2002-12-01), Hawiger et al.
patent: 6562798 (2003-05-01), Schwartz
patent: 6740514 (2004-05-01), Curtis
patent: 7160694 (2007-01-01), Fraser
patent: 2006/008759 (2006-01-01), None
Levitskaya, et al, “Inhibition of antigen processing by the internal repeat region of the Epstein-Barr virus nuclear antigen-1”, Nature, vol. 375, pp. 685-688; 1995.
Andersen, et al, “Structure and Mapping of Antigenic Domains of Protein Antigen b, a 38,000-Molecular-Weight Protein ofMycobacterium tuberculosis”, Infection and Immunity, vol. 57(8), pp. 2481-2488; 1989.
Young, et al, “Immunological Activity of a 38-Kilodalton Protein Purified fromMycobacterium tuberculosis”, Infection and Immunity, vol. 54(1), pp. 177-183; 1986.
Benetiz, et al, “A recombinant protein based immunoassay for the combined detection of antibodies to HIV-1, HIV-2, and HTLV-1”, Journal of Virological Methods, vol. 70, pp. 85-91; 1998.
Liljeqvist, et al, “Localization of type-specific epitopes of herpes simplex virus type 2 glycoprotein G recognized by human and mouse antibodies”, Journal of General Virology, vol. 78, pp. 1215-1224; 1998.
Delugo, et al, “Comparative Immune Response to PE and PE—PGRS Antigens ofMycobacterium tuberculosis”, Infection and Immunity, vol. 69(9), pp. 5606-5611; 2001.
Singh, et al, “Antigens ofMycobacterium tuberculosisExpressed during Preclinical Tuberculosis: Serological Immunodominance of Proteins with Repetitive Amino Acid Sequences”, Infection and Immunity, vol. 69(6), pp. 4185-4191; 2001.
Banu, et al, “Are the PE-PGRS proteins ofMycobacterium tuberculosisvariable surface antigens?”, Molecular Microbiology, vol. 44(1), pp. 9-19; 2002.
Sampson, et al, “Expression, characterization and subcellular localization of theMycobacterium tuberculosisPPE gene Rv1917c”, Tuberculosis, vol. 81(5/6), pp. 305-317; 2001.
Brennan, et al, “Evidence that Mycobacterial PE—PGRS Proteins Are Cell Surface Constituents That Influence Interactions with Other Cells”, Infection and Immunology, vol. 69(12), pp. 7326-7333; 2001.
Espitia, et al, “The PE-PGRS glycine-rich proteins ofMycobacterium tuberculosis: a new family of fibronectin-binding proteins?”, Microbiology, vol. 145, pp. 3487-3495; 1999.
Vega-Lopez, et al, “Sequence and Immunological Characterization of a Serine-Rich Antigen fromMycobacterium leprae”, Infection and Immunology, vol. 61(5), pp. 2145-2153; 1993.
Cole, Stewart T., “Comparative and functional genomics of theMycobacterium tuberculosiscomplex”, Microbiology, vol. 148, pp. 2919-2928; 2002.
Wilkinson, et al, “Peptide-Specific T Cell Response toMycobacterium tuberculosis: Clinical Spectrum, Compartmentalization, and Effect of Chemotherapy”, The Journal of Infectious Diseases, vol. 170, pp. 760-768; 1998.
Miguez, et al, “Evaluation of the Serologic Response against Two Consensus V3 Loop Peptides from Human Immunodificiency Virus-1 in Cuban Patients”, Int J Dis, vol. 2, pp. 221-225; 1998.
Cole, et al, “Deciphering the biology ofMycobacterium tuberculosisfrom the complete genome sequence”, Nature, vol. 393, pp. 537-544; 1998.
Poulet, et al, “Characterization of the highly abundant polymorphic GC-rich-repetitive sequence (PGRS) present inMycobacterium tuberculosis”, Arch Microbiol, vol. 163, pp. 87-95; 1995.
Abou-Zeid, et al, “Genetic and Immunological Analysis ofMycobacterium tuberculosisFibronectin-Binding Proteins”, Infection and Immunity, vol. 59(8), pp. 2712-2718; 1991.
Ramakrishnan, et al, “Granuloma-Specific Expression ofMycobacteriumVirulence Proteins from the Glycine-Rich PE-PGRS Family”, Science, vol. 288, pp. 1436-1439; 2000.
Choudhary, et al, “Expression and characterization of Rv2430c, a novel immunodominant antigen ofMycobacterium tuberculosis”, Protein Expression and Purification, vol. 36, pp. 249-253; 2004.
Chakhaiyar, et al, “Defining the Mandate of Tuberculosis Research in a Postgenomic Era”, Med Princ Pract, vol. 13, pp. 177-184; 2004.
Young, et al, “Heat Shock Proteins and Antigens ofMycobacterium tuberculosis”, Infection and Immunology, vol. 59 (9), pp. 3086-3093; 1991.
Chakhaiyar, et al, “Regions of High Antigenicity within the Hypothetical PPE Major Polymorphic Tandem Repeat Open-Reading Frame, Rv2608, Show a Differential Humoral Response and a Low T Cell Response in Various Categories of Patients with Tuberculosis”, Journal Infectious Disease, vol. 190, pp. 1237-1244; 2004.
Choudhary, et al, “PPE Antigen Rv2430c ofMycobacterium tuberculosisInduces a Strong B-Cell Response”, Infection and Immunology, vol. 71(11), pp. 6338-6343; 2003.
Database entry Q79FC6(PPE42—MYCTU); Retrieved from UNIPROT EBI Database—http://www.uniprot.org/uniprot/Q79FC6.

Affiliated with

Also associated with

Rating

Antigenic peptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antigenic peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antigenic peptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4296184