Antifungal S-ethers of 2-aryl-3-mercapto-1-(1H-1,2,4-triazol-1-y

Details Antifungal S-ethers of 2-aryl-3-mercapto-1-(1H-1,2,4-triazol-1-y Antifungal S-ethers of 2-aryl-3-mercapto-1-(1H-1,2,4-triazol-1-y

1984-08-28

1987-04-28

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548262, C07D24908, A61K 3141

Patent

active

046615075

ABSTRACT:
Compounds of the general formula: ##STR1## wherein R is naphthyl, biphenylyl, phenyl or substituted phenyl; n is 0, 1 or 2; and R.sup.1 is H, C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl, C.sub.2-4 alkanoyl, or C.sub.1-2 alkyl substituted by C.sub.2-4 alkenyl with the provisos that when R.sup.1 is H or C.sub.2-4 alkanoyl, n is 0; and when n is 2, R.sup.1 is C.sub.1-3 alkyl; and their pharmaceutically acceptable salts are antifungal agents useful in combatting fungal infections in animals, including humans.

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