Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-05-11
2008-10-28
Saeed, Kamal (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C549S458000, C548S439000, C548S448000, C562S452000, C562S466000, C514S443000, C514S468000, C514S411000, C514S569000, C514S567000
Reexamination Certificate
active
07442808
ABSTRACT:
Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
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patent: 3514491 (1970-05-01), Hanessian et al.
patent: 2003/0069224 (2003-04-01), Lindstrom et al.
patent: WO 02/070516 (2002-09-01), None
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patent: WO 2005/066131 (2005-07-01), None
Ge Min
He Jiafang
Lau Fiona Wai Yu
Liang Gui-Bai
Lin Songnian
Bianchi Kristin
Durette Phillippe L.
Fitch Catherine D.
Merck & Co. , Inc.
Saeed Kamal
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