Antidepressant N-substituted nicotinamide compounds

Details Antidepressant N-substituted nicotinamide compounds Antidepressant N-substituted nicotinamide compounds

1988-08-31

1989-08-29

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546273, 546291, C07D40112

Patent

active

048618918

ABSTRACT:
Certain N-substituted nicotinamide compounds having formula (I) below ##STR1## and pharmaceutically acceptable acid addition salts thereof wherein R.sup.1 is 1-piperidyl, 1-(3-indolyl)ethyl, C.sub.1-4 alkyl, phenyl, 1-(1-phenylethyl), benzyl or mono-substituted benzyl wherein the substituent is methyl, methoxy, chloro or fluoro; and R.sup.2 is bicyclo[2.2.1]hept-2-yl or ##STR2## wherein Y is hydrogen, fluoro or chloro; and X is hydrogen, fluoro, chloro, methoxy, trifluoromethyl, cyano, carboxy, carbo (C.sub.1-4 alkoxy), methylcarbamoyl or dimethylcarbamoyl function as selective inhibitors of calcium-independent phosphodiesterase and are useful as antidepressants.

REFERENCES:
patent: 4251263 (1981-02-01), Gutman
patent: 4270946 (1981-06-01), Gutman
patent: 4618366 (1986-10-01), Cramp et al.

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