Antibody to GALP and uses thereof

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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C424S130100, C530S388100

Reexamination Certificate

active

10490917

ABSTRACT:
The present invention intends to provide a novel monoclonal antibody having a binding specificity to GALP or its derivative, which is useful in developing therapeutic agents, preventive agents or diagnostic agent for diseases associated with GALP or its derivative, and a method of quantifying GALP using the antibody. More specifically, the present invention provides an antibody specifically reacting with a partial peptide in the C-terminal region of a polypeptide having the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3, or its derivative, and a method of quantifying GALP or its derivative.

REFERENCES:
patent: 2004/0077531 (2004-04-01), Matsumoto et al.
patent: 2323503 (1999-03-01), None
patent: 1 065 214 (2001-01-01), None
patent: 1 275 659 (2003-01-01), None
patent: 2000-197483 (2000-07-01), None
patent: 2000-270871 (2000-10-01), None
patent: WO 01/27273 (2001-04-01), None
patent: WO 01/77166 (2001-10-01), None
Fujiwara et al., “Immunocytochemical localization of galanin-like peptide (GALP) in pitulcytes of the rat posterior pituitary gland”, Neuroscience Letters, 317(2):65-68 (2002).
Y. Takatsu et al.,Endocrinology, vol. 142, No. 4, pp. 1626-1634, 2001.
T. Ohtaki et al.,Journ. of Bio. Chem., vol. 274, No. 52, pp. 37041-37045. 1999.

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