Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se
Reexamination Certificate
2005-01-04
2005-01-04
Stucker, Jeffrey (Department: 1648)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Primate cell, per se
C435S041000, C435S325000, C435S372100, C435S372200, C435S372300
Reexamination Certificate
active
06838282
ABSTRACT:
The subject invention pertains to antibodies that have binding specificity for an antigen that is expressed on a subset of human, hematopoietic mononuclear cells, including a hematopoietic stem cell population, but is not expressed on normal, mature myeloid cells. In one embodiment, a monoclonal antibody, MG1, is provided. This antibody is useful in methods of isolating cell suspensions from human blood and marrow that can be employed in bone marrow transplantation, genetic therapy, and in treating other diseases of the hematopoietic system. Cell suspensions containing MG1+human hematopoietic cells are also provided, as well as therapeutic methods employing the cell suspensions. The subject invention also pertains to the novel antigen recognized by the subject antibodies.
REFERENCES:
patent: 4714680 (1987-12-01), Civin
patent: 5061620 (1991-10-01), Tsukamoto et al.
patent: 5585089 (1996-12-01), Queen et al.
patent: 0895670 (1983-05-01), None
patent: WO 9325216 (1993-12-01), None
patent: WO 9402157 (1994-02-01), None
patent: WO 9503693 (1995-02-01), None
patent: WO 9615229 (1996-05-01), None
Bodger, M.P. et al. (1981) “A monoclonal antibody specific for immature human hemopoietic cells and T lineage cells”Journal of Immunology, vol. 127, No. 6, pp. 2269-2274.
Ritz, J. et al. (1980) “A monoclonal antibody to human acute lymphoblastic leukaemia antigen”Nature, vol. 283, pp. 583-585.
Civin, C.I. et al. (1984) “Antigenic Analysis of Hematopoiesis III. A Hematopoietic Progenitor Cell Surface Antigen Defined by a Monoclonal Antibody Raised against KG-1a Cells”Journal of Immunology, vol. 133, No. 1, pp. 157-165.
Craig, W. et al. (1993) “Expression of Thy-1 on Human Hematopoietic Progenitor Cells”J. Ex. Med., vol. 177, pp. 1331-1342.
Berenson, R.J. et al. (1988) “Antigen CD34* Marrow Cells Engraft Lethally Irradiated Baboons”J. Clin. Invest., vol. 81, pp. 951-955.
Terstappen, L.W. (1990) “Flow Cytomeric Analysis of Human Bone Marrow III. Neutrophil Maturation”Leukemia, vol. 4, No. 9, pp. 657-663.
Loken, M.R. et al. (1987) “Flow Cytometric Analysis of Human Bone Marrow II. Normal B. Lymphocyte Development”Blood, vol. 70, No. 5, pp. 1316-1324.
Friedmann, T. (1989) “Progress Toward Human Gene Therapy”Science, vol. 244, pp. 1275-1281.
Sutherland, H.J. et al. (1991) “Differential Regulation of Primative Human Hematopoietic Cells in Long-Term Cultures Maintained on Genetically Murine Stromal Cells”Blood, vol. 78, No. 3, pp. 666-672.
Terstappen, L.W. et al. (1991) “Sequential Generations of Hematopoietic Colonies Derived From Single Nonlineage-Committed CD34*CD38* Progenitor Cells”Blood77(6):1218-1227.
Bender, J.G. et al. (1991) “Identification and Comparison of CD34-Positive Cells and Their Subpopulations From Normal Peripheral Blood and Bone Marrow Using Multicolor Flow Cytometry”Blood, vol. 77, No.12, pp. 2591-2596.
Terstappen, L.W. et al. (1991) “Sequential Generations of Hematopoietic Colonies Derived From Single Nonlineage-Committed CD34*CD38* Progenitor Cells”Bloodvol. 77, No. 6, pp. 1218-1227.
Loken, M.R. et al. (1987) “Flow Cytometric Analysis of Human Bone Marrow I. Normal Erythroid Development”Blood, vol. 69, No. 1, pp. 255-263.
Simmons, P.J. et al. “Identification of Stromal Cell Precursors in Human Bone Marrow by a Novel Monoclonal Antibody, STRO-1”Blood(1991), vol. 7B, No. 1, 55-62.
Golde, D.W. (1991) “The Stem Cell”Scientific Americanvol. 265, No. 6, pp. 86-93.
No Authors Listed, “Gene Therapy in Man”,The Lancet(1988), vol. 1, pp. 1271-1272.
Lawman Michael J. P.
Lawman Patricia
Morphogenesis, Inc.
Saliwanchik, Lloyd & Saliwanchick
Stucker Jeffrey
LandOfFree
Antibody recognizing a small subset of human hematopoietic... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antibody recognizing a small subset of human hematopoietic..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibody recognizing a small subset of human hematopoietic... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3400845