Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1998-01-30
2000-03-28
Park, Hankyel
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
5303895, 435 74, 435 34, 435 39, G01N 3353, G01N 33573, G07K 1600, C12Q 104, C12Q 106
Patent
active
060430427
ABSTRACT:
A toxin assay that uses a substrate for cleavage by the toxin and antibodies that do not recognize the substrate but recognize and bind to the product of cleavage of the substrate by the toxin. The substrate can be a nerve cell peptide when the assay is for botulinum toxin or tetanus toxin.
REFERENCES:
patent: 5171662 (1992-12-01), Sharma
Schiavo, et al., Tetanus and botulinum-B neurotoxins block neutransmitter release by proteolytic cleavage of synaptobrevin, Nature, vol. 359, pp. 832-835, see entire article. Oct. 1992.
Sollner, et al., Snap receptors implicated in vesicle targeting and fusion, Nature, vol. 362, pp. 318-324, Mar. 1993.
Doellgast, et al., Sensitive Enzyme-Linked Immunosorbent Assay for Detection of Clostridium botulinum Neurotoxins A, B, and E Using Signal Amplification via Enzyme-Linked Coagulation Assay, J. Clin. Microbiol., vol. 31, No. 9, pp. 2402-2409, see page 2402, Sep. 1993.
Foran, P. et al., "Differences in the Protease Activities of Tetanus and Botulinum B Toxins Revealed by the Cleavage of Vesicle-Associated Membrane Protein and Various Sized Fragments," Biochem. 33:15365-15374 (Dec. 27, 1994).
Rossetto, O. et al., "Snare Motif and Neurotoxins," Nature 372:415-416 (Dec. 1, 1994).
Shone, C. and Roberts, A., "Peptide Substrate Specificity and Properties of the Zinc-Endopeptides Activity of Botulinum Type B Neurotoxin," Eur. J. Biochem. 225:263-270 (Oct. 1, 1994).
Oyler, G.A. et al., "The Identification of a Novel Synaptosomal-associated Protein, Snap-25, Differentially Expressed by Neuronal Subpopulations," J. Cell. Bio. 109:3039-3052 (1989).
Hallis Bassam
James Benjamin Arthur Frederick
Quinn Conrad Padraig
Shone Clifford Charles
Microbiobiological Research Authority
Park Hankyel
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