Neurokinin antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514277, 514311, 514307, 544402, 544162, 544392, 544396, 546124, 564182, 564185, 564306, 564 48, A61K 31495, C07D29504

Patent

active

059858818

ABSTRACT:
The invention relates to new compounds of general formula I ##STR1## and the pharmaceutically acceptable salts thereof, wherein A, B, Z, R.sup.1, R.sup.2, R.sup.3 and m are defined as in the specification, processes for preparing them and pharmaceutical compositions containing these compounds. The compounds are valuable neurokinin (tachykinin) antagonists.

REFERENCES:
patent: 3862946 (1975-01-01), Havera
patent: 5696123 (1997-12-01), Dollinger et al.
Colten, H.R. and Krause, J.E., "Pulmonary Inflammation--A Balancing Act," New Engl. J. Med.336:1094-1096 (Apr. 1997).
Lowe,III, Nonpeptide Tachy Kinin Antagonists, Med Res Rev. vol. 16, No. 6 527-545; 1996.
McLean., Antagonists of NKI Receptor Med Res Rev., vol. 16, No. 4, 297-317; 1996.
Henry., Substance P . . . . ,; 1993 Inflammatory Disease Therapy Ed: Bonney, 1993.
Moussaoui et al., European J. Pharmacol., 238, 1993 Nayes 421-424.

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