Antibodies to insulin/IGF/relaxin family polypeptides

Details Antibodies to insulin/IGF/relaxin family polypeptides Antibodies to insulin/IGF/relaxin family polypeptides

2005-11-21

2008-08-12

Saoud, Christine J (Department: 1647)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

C435S326000, C530S388100, C424S141100

Reexamination Certificate

active

07410641

ABSTRACT:
The present invention relates to antibodies that bind to the A chain N-terminal peptide. The present invention also relates to (1) a polypeptide containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:7 (A chain), (2) a polypeptide containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:8 (B chain), (3) a polypeptide wherein the A and B chains are bonded to each other via disulfide bonds (2 chains) or its salt., (4) DNAs encoding the same, etc. These polypeptides and DNAs encoding the same can be used for the diagnosis, treatment, prevention, etc. for diseases, including abnormalities (e.g., diabetes mellitus, etc.) in metabolic regulation (sugar metabolism, lipid metabolism, etc.) of energy sources such as carbohydrates.

REFERENCES:
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patent: WO 01/68862 (2001-09-01), None
patent: WO 02/22802 (2002-03-01), None
Bullesbach et al., SEQ ID No. 7 sequence alignment result.
Bullesbach et al., SEQ ID No. 8 sequence alignment result.
Bullesbach, E., et al., “The Relaxin-Like Factor is a Hormone”,Endocrine, (1999), vol. 10, No. 2, pp. 167-169.
Bani, D., “Relaxin: A Pleiotropic Hormone”,Gen. Pharmac. (1997), vol. 28, No. 1, pp. 13-22.
Berger, S., et al., “Statistical Approach for Evolutionary Relationship of a-Conotoxins and Members of Insulin-Superfamily”,Horm. Metab. Res., (1996), vol. 28, pp. 535-540.
James, R. et al., “Primary Structure of Porcine Relaxin: Homolgy with Insulin and Related Growth Factors”,Nature, (1977), vol. 267, pp. 544-546.
Haley, J., et al., “Porcine Relaxin”,The Journal of Biological Chemistry, (1987), vol. 262, No. 25, pp. 11940-11946.
Gowan, L., et al., “On the Primary and Tertiary Structure of Relaxin from the Sand Tiger Shark (Odontaspis taurus)”,FEBS Letters, (1981), vol. 129, No. 1, pp. 80-82.
Bullesbach, E., et al., Isolation, Purification, and the Sequence of Relaxin from Spiny Dogfish (Squalus acanthias),Eur. J. Biochem., (1986), vol. 161, pp. 335-341.
XP-002282992, Jan. 27, 2000, EMBL:AC022098.

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