Antibodies specific for OVCA DNA encoded proteins and methods fo

Details Antibodies specific for OVCA DNA encoded proteins and methods fo Antibodies specific for OVCA DNA encoded proteins and methods fo

1995-06-22

1998-10-13

Scheiner, Aoni R.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

5303879, 5303882, 5303888, 5303897, C07K 1618

Patent

active

058213384

ABSTRACT:
This invention provides a novel gene, OVCA1, isolated from human chromosome 17p13.3. Disruption of the OVCA1 gene is associated with cellular proliferation and tumor development. The OVCA1 gene, along with its encoded protein and antibodies thereto, provides a biological marker for early diagnosis of metastatic disease. The gene also will be useful in gene replacement therapy for treating various forms of cancer.

REFERENCES:
Foulkes Int. J.Cancer 54: 220-225, 1993.
Nakamura, Nucleic Acid Res. 16:782 1988.
Schultz, Am. J. Hum. Genet. 57(4 Suppl):A4 1995.

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