Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1988-02-16
1990-09-18
Nucker, Christine
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
530387, 436548, 436501, 436518, 436530, 436536, 436538, 935104, 935110, G01N 3353, G01N 33543, G01N 33544
Patent
active
049578596
ABSTRACT:
Preparation of novel polypeptide sequences spanning amino acid position 61 of the ras protein, said sequences being characterized as containing a leucine in that position instead of the glutamine found in normal ras protein, the utilization of such polypeptides to prepare immunogen compositions utilizing such polypeptide covalently linked to immunogenic carrier materials, the production of antibodies elicited by such polypeptides, the screening of such antibodies to provide monoclonals specific to the P21Tleu61 transforming protein and to immunoassay and use in immunochemical methods employing such antibodies to determine the presence of the p21TLeu61 transforming protein.
REFERENCES:
patent: 4786718 (1988-11-01), Weinberg et al.
Cetus Diagnostics Brochure, Mouse Monoclonal Antibody.
Guenero et al., PNAS 82, pp. 7810-7814, 1985.
Bizub et al, PNAS 83, pp. 6048-6052, 1986.
Lerner, Nature, 299, pp. 592-596, 1982.
Clark et al., Proc. Natl. Acad. Sci., USA 82, pp. 5280-5284, (1985).
Niman et al., Proc. Natl. Acad. Sci., USA 82, pp. 7924-7928, (1985).
Bizub Diane
Fischberg-Bender Ellyn
Skalka Anna M.
Esptein William H.
Gould George M.
Hoffmann-La Roche Inc.
Krupen Karen I.
Nucker Christine
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