Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...
Reexamination Certificate
2011-08-23
2011-08-23
Jiang, Dong (Department: 1646)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Structurally-modified antibody, immunoglobulin, or fragment...
C530S388230, C530S387300, C530S351000, C530S809000, C435S069100
Reexamination Certificate
active
08003099
ABSTRACT:
An antibody binding to IL-17 characterized by binding to the same IL-17 epitope to which monoclonal antibody 3C1 binds, and being of human IgG1 isotype modified in the hinge region at amino acid position 216-240, preferably at amino acid position 220-240, between CH1 and CH2 and/or in the second inter-domain region at amino acid position 327-331 between CH2 and CH3 has advantageous properties for the treatment of inflammatory diseases.
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Ziolkowska, M., et. al. “High Levels of IL-17 in Rheumatoid Arthritis Patients: IL-15 Triggers In Vitro IL-17 Production Via Cyclosporin A-Sensitive Mechanism1,” The American Association of Immunologists, 2000, vol. 164, pp. 2832-2838.
Auer Johannes
Dimoudis Nikolaos
Georges Guy
Hanke Petra
Knoetgen Hendrik
Hall Robert C.
Jiang Dong
Roche Palo Alto LLC
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