Antibiotics tetronolide compounds and process for production the

Details Antibiotics tetronolide compounds and process for production the Antibiotics tetronolide compounds and process for production the

1981-06-15

1983-07-12

Love, Ethel G.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 71, 536 168, 549265, 549268, A61K 3171, C07G 1100

Patent

active

043930565

ABSTRACT:
New antibacterial tetronolide compounds F-1 and F-2 are produced by fermentation of a microorganism belonging to the genus Micromonospora. The antibiotics F-1 and F-2 are accumulated in the culture liquor and are isolated therefrom respectively and the acyl derivatives of F-1 and F-2, that is, F-1-21-O-acetate, F-1-21-O-propionate, F-1-21-O-n-butylate, F-1 diacetate, F-1 dipropionate, F-2 triacetate, F-2 tripropionate and F-2 tri-n-butylate, etc., are synthesized from F-1 and F-2 by known means.

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patent: 4161523 (1979-07-01), Weinstein et al.
patent: 4346075 (1982-08-01), Tomita et al.
J. of Antibiotics, vol. 33, No. 6, pp. 668-670, Jun. 1980, "Novel Antitumor Antibiotics, Tetrocarcins", F. Tomita, et al.
J. of Antibiotics, vol. 33, No. 9, pp. 940-945, Sep. 1980, "Tetrocarcins, Novel Antitumor Antibiotics", F. Tomita, et al.
J. of Antibiotics, vol. 33, No. 9, pp. 946-950, Sep. 1980, "Tetrocarcins, Novel Antitumor Antibiotics", T. Tamaoki, et al.
Tetrahedron Letters, vol. 21, pp. 2559-2560, 1980, "The Structure of Tetronolide . . . ", Hirama, et al.
23rd Symposium Papers, pp. 584-591, Oct. 1980, (The Chemistry of Natural Product).
J. Antibiotics, vol. 33, 244-246, Feb. 1980, "A New Antibiotic, Antlermicin A", Kobinta, et al.

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