Antibiotics of the mureidomycin group, their preparation, and th

Details Antibiotics of the mureidomycin group, their preparation, and th Antibiotics of the mureidomycin group, their preparation, and th

1988-11-17

1991-08-20

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 530330, 530331, A61K 3702, C07K 508, C07K 510

Patent

active

050414232

ABSTRACT:
New antibiotics of the mureidomycin group have the formula ##STR1##
wherein X represents the group ##STR2##
and wherein R represents hydrogen, an alkyl group having from 1 to 10 carbon atoms, an alkenyl group having from 2 to 7 carbon atoms, an alkynyl group having from 3 to 7 carbon atoms, an aryl group having from 6 to 10 carbon atoms, an aralkyl group having from 7 to 10 carbon atoms, or one of the said aryl or aralkyl groups substituted with at least one substituent selected from halogen and alkyl groups having from 1 to 5 carbon atoms. The compound in which X represents 8-hydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl is named mureidomycin E and the compound in which X represents 6-hydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl is named mureidomycin F. This group of compounds and their pharmaceutically acceptable esters and salts are useful as antibiotics for the treatment of bacterial infections. Mureidomycins E and F can be obtained by fermentation of a suitable Streptomyces strain, in particular Streptomyces flaviodovirens SANK 60486 (BIKOKEN JOHKI 1347; FERM BP-1347). Alternatively, all of the compounds can be obtained synthetically by reacting the previously known compound mureidomycin A with an aldehyde of the formula

REFERENCES:
patent: 4670542 (1987-06-01), Benz et al.
patent: 4722924 (1988-02-01), Baldwin
patent: 4748155 (1988-05-01), Sisto et al.

Affiliated with

Also associated with

Rating

Antibiotics of the mureidomycin group, their preparation, and th does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibiotics of the mureidomycin group, their preparation, and th, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibiotics of the mureidomycin group, their preparation, and th will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1007987