Antibiotic tan-749, its derivatives, production and use thereof

Details Antibiotic tan-749, its derivatives, production and use thereof Antibiotic tan-749, its derivatives, production and use thereof

1987-12-07

1990-03-06

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

N-c doai

424116, 514564, 514626, 514631, 560159, 560160, 560169, 562561, 562564, 564197, 564225, C07C12300, A61K 3500

Patent

active

049066595

ABSTRACT:
A compound of the formula ##STR1## wherein R.sup.1 and R.sup.4 are independently amino or an organic residue bonded through nitrogen, R.sup.2 is hydrogen or alkyl which may be substituted, R.sup.3 is hydrogen or a protecting group and R5 is hydroxyl which may be substituted or amino which may be substituted or salts thereof; with the proviso that when R.sup.1 is amino, leucylamino, acetylamino or benzyloxycarbonylamino, R.sup.3 is hydrogen, methyl or 2-tettrahydropyranyl, R.sup.4 is amino, acetylamino or benzyloxycarbonylamino and R.sup.5 is hydroxyl which may be substituted or amino which may be substituted, R.sup.2 is alkyl which may be substituted, has antibacterial activities against drug-resistant bacteria and therefore can be useful as a chemotherapeutic drug for bacterial infections in mammals.

REFERENCES:
patent: 3743580 (1973-07-01), Umezawa et al.
Shibihara et al., J. Am. Chem. Soc., vol. 94, No. 12, pp. 4353-4354, 1972.
Kondo et al., The Journal of Antibiotics, vol. 24, No. 10, pp. 732-734 (1971).
Kondo et al., Journal of the American Chemical Society, vol. 93, pp. 6305-6306 (1971).
Uehara et al., The Journal of Antibiotics, vol. 29, No. 9, pp. 937-942 (1976).
Pierdet et al., Tetrahedron, vol. 36, pp. 1763-1772 (1980).
Streicher et al., the Journal of Antibiotics, vol. 31, No. 7, pp. 725-728 (1978).
Kondo et al., The Journal of Antibiotics, vol. 29, No. 2, pp. 208-210 (1976).

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