Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1996-03-28
1998-01-13
Marx, Irene
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
514443, 548101, 548104, 548105, 548148, C12P 1716, A61K 3138, A61K 31425, C07D27756
Patent
active
057078386
DESCRIPTION:
BRIEF SUMMARY
DETAILED DESCRIPTION OF THE INVENTION
1. Field of the Invention
The present invention relates to a novel useful compound in the field of medicine and veterinary medicine, a process for preparation thereof and a pharmaceutical composition containing said compound.
2. Background of the Invention
Mycoplasmas have a wide distribution throughout domestic animals such as swine, cattle and sheep; domestic fowls such as chickens, turkeys and pheasant; insects; and plants, as well as human, and there exist many species of Mycoplasma for each of those animals.
For human, Mycoplasmas have attracted the attention of people as causative bacteria of pneumonia and upper respiratory inflammation, and recently, relation between infections of Mycoplasmas and other diseases, especially AIDS, is taken notice of people.
The bacteria cause various diseases such as epidemic pneumonia in swine, respiratory mycoplasmosis and infectious synovitis in chickens, and airsacculitis and infectious sinusitis in turkeys. These diseases are not caused only by Mycoplasma alone but can be accompanied by complications caused by infectious other microorganisms such as bacteria and viruses, which lead to a serious economic loss because, in such cases, the symptoms are severer and the diseases are chronic compared to those of infections with Mycoplasma alone.
Mycoplasmas also play an important role in infections of laboratory animals such as mice, rats and guinea pigs, and in contamination of tissue culture cells, which are all used for various studies, as well as infections of domestic animals and fowls.
OBJECT OF THE INVENTION
To prevent the infections and contaminations with Mycoplasma, macrolides and tetracyclines are often used because Mycoplasma is characterized by lacking the cell wall in its structure.
However, macrolides have been used for many years, and such long-term usage has led to developing many macrolides-resistant Mycoplasma strains, and the efficacy of tetracyclines is as well declining.
DESCRIPTION OF THE DRAWINGS
FIG. 1 shows UV absorption spectrum of B057-250A.
FIG. 2 shows infrared absorption spectrum of B057-250A.
FIG. 3 shows UV absorption spectrum of B057-250B.
FIG. 4 shows infrared absorption spectrum of B057-250B.
FIG. 5 shows UV absorption spectrum of B057-250C.
FIG. 6 shows infrared absorption spectrum of B057-250C.
FIG. 7 shows UV absorption spectrum of B057-250D.
FIG. 8 shows infrared absorption spectrum of B057-250D.
FIG. 9 shows UV absorption spectrum of B057-250E.
FIG. 10 shows infrared absorption spectrum of B057-250E.
DESCRIPTION OF THE INVENTION
The present inventors have found a new substance produced by Pseudomonas sp., and demonstrated that said substance had an anti-infection activity to Mycoplasma. Therefore, the new substance of the invention is considered to be very promising agent for prevention and/or treatment of Mycoplasmosis.
A compound of the present invention is represented by the formula: ##STR2## wherein M is a bivalent or trivalent metal ion, and X is OH or O.sup..crclbar..
The compound of the invention can be stereochemically represented by the formula: ##STR3## wherein each symbol is as defined above.
Bivalent or trivalent metal ions represented by M include Zn.sup.2+, Cu.sup.2+, Fe.sup.2+, Fe.sup.3+, Co.sup.2+, Ni.sup.2+, Mn.sup.2+, Cd.sup.2+, Mg.sup.2+, Ca.sup.2+, Sr.sup.2+, Ba.sup.2+, V.sup.2+, V.sup.3+, Cr.sup.2+, Al.sup.3+, Sn.sup.2+, Pb.sup.2+, Ag.sup.2+ or the like. Preferably, M is Zn.sup.2+, Cu.sup.2+, Fe.sup.2+, Fe.sup.3+, Co.sup.2+, Ni.sup.2+, Mn.sup.2+, Mn.sup.3+ and Cd.sup.2+, and more preferably, Zn.sup.2+, Cu.sup.2+, Fe.sup.3+, Co.sup.2+ and Ni.sup.2+.
A compound wherein M is Cu.sup.2+, Zn.sup.2+, Fe.sup.3+, Co.sup.2+ or Ni.sup.2+ is herein referred to as B057-250A (Cu-chelate), B057-250B (Zn-chelate), B057-250C (Fe-chelate), B057-250D (Co-chelate) or B057-250E (Ni-chelate), respectively. They are collectively referred to as compounds B057-250. Physical and chemical characteristics of the new compound B057-250are as follows: FIG. 2) MeOH) and insoluble in water, ace
REFERENCES:
patent: 4406905 (1983-09-01), Zahner et al.
Cox et al., Pyochelin: Novel structure of an iron-chelating growth promoter for Pseudomonas aeruginosa, Proc. Natl. Acad. Sci. USA, vol. 7, pp. 4256-4260, 1981.
Krieg, ed., Section 4. Gram-negative rods and cocci, In Bergey's Manual of Systematic Bacteriology, vol. 1, Williams and Wilkins, MD p. 165, 1984.
Hayase Yoshio
Hidaka Shigetada
Kobayashi Shinobu
Nakai Hiroshi
Ozaki Mamoru
Kerr Janet M.
Marx Irene
Shionogi & Co. Ltd.
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