Anti-tumor platinum complexes, their preparation and their thera

Details Anti-tumor platinum complexes, their preparation and their thera Anti-tumor platinum complexes, their preparation and their thera

1994-11-18

1996-06-18

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544 64, 544225, 546 5, 546 11, 546 12, 548104, 548109, 548403, C07F 1500, A61K 31555, C07D20508, C07D207277

Patent

active

055279058

ABSTRACT:
Compounds of formula (I): ##STR1## in which: A and B are separately monoamines or together diamines; and Z is a group of formula (II) or (III): ##STR2## (in which R.sup.1, R.sup.2 and R.sup.7 are various organic groups, n is 0, 1 or 2 and X is a direct carbon-carbon bond or lower alkylene) show valuable anti-tumor activity and may be prepared by reacting an amine-platinum complex with a compound providing the group represented by Z.

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Dermer, Bio/Technology, 12 Mar. 1994, p. 320.
Martin, Cancer. Treat. Reports 68, 1317 (1984).
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Yoshinori Kidani et al, "Antitumor Activity Of Platinum (II) Complexes of 1,2-Diaminocyclohexane Isomers", Gann, 71, 637-643 (1980).
Drugs of the Future, "Carboplatinum", 8, (6) 489-491 (1983).

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